| 章绪辉,罗良平,周序珑,陈金城.周围型非小细胞肺癌CT征象、预后与CD44v3、CD44v6表达的相关研究[J].中国医学影像技术,2009,25(7):1195~1198 |
| 周围型非小细胞肺癌CT征象、预后与CD44v3、CD44v6表达的相关研究 |
| Correlative study among CT signs, prognosis and the expression of CD44v3 and CD44v6 in peripheral non-small-cell lung cancer |
| 投稿时间：2008-10-24 修订日期：2009-03-20 |
| DOI： |
| 中文关键词: 肺肿瘤 免疫组织化学 体层摄影术,X线计算机 预后 |
| 英文关键词:Lung neoplasms Immunohistochemistry Tomography, X-ray computed Prognosis |
| 基金项目:广东省自然科学基金(5006074)。 |
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| 中文摘要: |
| 目的 探讨周围型非小细胞肺癌的CT征象、预后与CD44v3、CD44v6表达的相关性。 方法 经手术病理证实的46例周围型NSCLC患者进入研究。利用免疫组化SP法检测CD44v3、CD44v6在肺癌组织中的表达,分析其与肺癌CT征象及预后的关系。 结果 CD44v3、CD44v6表达与肺癌CT征象中的深分叶征、棘突征、短毛刺征及肺门、纵隔淋巴结增大密切相关(P＜0.05),与肿瘤大小、空泡征、血管集束征及胸膜凹陷征无明显相关性(P＞0.05);CD44v3、CD44v6表达与肺癌术后3年生存率密切相关(P＜0.05)。 结论 深分叶征、棘突征、短毛刺征及肺门、纵隔淋巴结增大与CD44v3、CD44v6表达明显相关,提示肺癌的侵袭、转移能力较强;CD44v3、CD44v6阳性表达的肺癌患者术后生存时间更短,预后更差。 |
| 英文摘要: |
| Objective To observe the relationship between CT signs, prognosis and the expression of CD44v3 and CD44v6 in peripheral non-small-cell lung cancer (NSCLC). Methods The expression of CD44v3 and CD44v6 was detected with immunohistochemistry (SP method) in 46 patients with peripheral NSCLC confirmed by surgery and pathology. The expression, CT signs and prognosis of NSCLC were analyzed respectively. Results The expression of CD44v3 and CD44v6 correlated with deep lobulation, spinous protuberant sign, short spiculation and lymph node enlargement of hila or mediastinum (P<0.05), but not with the tumor size, vacuole sign, vessel convergence sign and pleural indentation in CT images of peripheral NSCLC (P＞0.05). The expression of CD44v3 and CD44v6 correlated with the three-year survival rate in peripheral NSCLC patients (P<0.05). Conclusion Deep lobulation, spinous protuberant sign, short spiculation and lymph node enlargement of hila or mediastinum may indicate strong potential invasion and metastasis in peripheral NSCLC. The positive expression of CD44v3 and CD44v6 may suggest shorter survival time and poorer prognosis in peripheral NSCLC patients. |
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