| 杨秀军,任其乐,李巍,胥文娟.减影CT灌注成像技术及对犬股骨头坏死观察应用[J].中国医学影像技术,2009,25(7):1131~1133 |
| 减影CT灌注成像技术及对犬股骨头坏死观察应用 |
| Subtraction computed tomographic perfusion imaging and observation of ischemic necrosis of femoral head on dog |
| 投稿时间：2009-04-01 修订日期：2009-05-27 |
| DOI： |
| 中文关键词: 股骨头坏死 模型,动物 体层摄影术,X线计算机 灌注 减影技术 |
| 英文关键词:Femoral head necrosis Models, animal Tomography, X-ray computed Perfusion Subtraction technique |
| 基金项目:上海市基础研究重点项目(05JC4089)。 |
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| 中文摘要: |
| 目的 探讨减影计算机体层摄影灌注成像(sCTP)技术及观察犬缺血性股骨头坏死的方法与可行性。 方法 对16只犬于旋股动脉内结扎术前后行股骨头CTP扫描,以观察股骨头坏死。在AW 4.2工作站利用减影软件对CTP源影像进行减影处理,再以Perfusion 3软件对减影图像数据和源影像数据分别作血流量(BF)、血容量(BV)、平均通过时间(MTT)色阶图分析并测量兴趣区其参数值。 结果 ①对CTP源影像减影所得新图像数据行灌注成像软件后处理成功率为100%,均获得了BF、BV、MTT色阶图及其数值,sCTP后处理时间约需1~5 h;②sCTP提供的BF、BV、MTT数值及色阶图能对比显示股骨头坏死,常规骨CTP难以揭示这些改变。 结论 sCTP技术可行,适用于骨的CT灌注成像、定量诊断骨坏死。 |
| 英文摘要: |
| Objective To investigate the technical protocols and feasibility of subtraction computed tomography perfusion imaging (sCTP) on observation of ischemic necrosis of femoral head (ANFH) on dog. Methods Sixteen laboratory canines underwent CT perfusion imaging (CTP) of femoral head before and after selective femoral circumflex artery embolization, and ANFH were observed. Then new sequence imaging data, created by sources imaging of CT perfusion scan using subtraction software, were analyzed at workstation (AW 4.2) with CT perfusion 3 analysis program, and data of sCTP were obtained. The parametric maps and indexes of capillary-level hemodynamics including blood volume (BV), blood flow (BF) and mean transit time (MTT) of CTP and sCTP were compared. Results ①The technical success rate of sCTP post-processing created from CTP sources imaging data was 100%. The values and mappings of BF, BV and MTT of region of interest (ROI) were all obtained from subtraction sequence images data. The post-processing time of sCTP was about 1-5 h. ② sCTP depicted ANFH well, though the values and mappings of BF, BV and MTT were different from those obtained with conventional bone CTP. Conclusion sCTP can be generated with subtraction and perfusion analysis program and techniques. It can be applied to bone CT perfusion imaging and early quantitative diagnosis of necrosis. |
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