| 裴新龙,谢敬霞,李选.MR扩散成像初步观察慢性肾病患者肾脏[J].中国医学影像技术,2009,25(5):841~843 |
| MR扩散成像初步观察慢性肾病患者肾脏 |
| Preliminary observation of chronic kidney disease with MR diffusion-weighted imaging |
| 投稿时间：2008-10-17 修订日期：2009-02-10 |
| DOI： |
| 中文关键词: 慢性肾病 磁共振成像 |
| 英文关键词: Chronic kidney disease Magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨扩散加权成像对于评价慢性肾病肾功能的意义。 方法 选择慢性肾病患者26例以及正常对照22例(除外肾脏病变),采用呼吸门控技术,行扩散加权成像,使用SE-EPI序列,选择扩散敏感因子b值分别为0、50、100、300、500、700 s/mm2,计算并比较两组肾实质ADC值,并将ADC值分别与血清肌酐和尿素氮水平进行相关性分析。 结果 随着b值的升高,肾实质ADC值呈现降低的趋势。当b值为50、100、300 s/mm2时病例组ADC值与对照组没有明显差异;b值为500、700 s/mm2时对应病例组ADC值较对照组降低(P<0.05)。b值为500、700 s/mm2时对应ADC值与sCr存在一定的负性相关关系(r值分别为-0.423和-0.494,P<0.05);b值为700 s/mm2时对应ADC值与BUN存在一定的负性相关关系(r=-0.466,P<0.05)。 结论 扩散加权成像能够反映慢性肾病肾功能的状态,高b值对应ADC与sCr和BUN呈一定的负相关关系,对于无创性评价肾脏功能具有重要的价值。 |
| 英文摘要: |
| Objective To evaluate renal function of chronic kidney failure with diffusion-weighted imaging (DWI). Methods Twenty-six patients with chronic kidney failure and 22 healthy subjects underwent diffusion-weighted echoplanar MR imaging (EPI) by breath-gating with six different strengths of motion probing gradients (b=0, 50, 100, 300, 500,700 s/mm2). Apparent diffusion coefficient (ADC) was calculated from different b-value and compared. Correlation between ADC and sCr/BUN level was evaluated. Results ADC value tended to decrease with increase of b value. At lower b values (b=50, 100, 300 s/mm2), no statistical difference of ADC values was found between patients and controls, while ADC values of patients declined obviously than healthy subjects at higher b values (b=500, 700 s/mm2, P<0.05). ADC values (b=500, 700 s/mm2) were negatively relative to the sCr level (r=-0.423, r=-0.494, respectively, P<0.05), and were negatively relative to the BUN level (b=700 s/mm2, r=-0.466, P<0.05). Conclusion Diffusion-weighted MR imaging is a potential method in noninvasively evaluating renal dysfunction of chronic kidney failure. |
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