| 于德新,马祥兴,张晓明,侯金文,李传福.不同b值和测量位置的DWI参数鉴别诊断肝脏良、恶性占位性病变[J].中国医学影像技术,2009,25(5):830~832 |
| 不同b值和测量位置的DWI参数鉴别诊断肝脏良、恶性占位性病变 |
| DWI parameters in differential diagnosis of benign and malignant liver lesions with different b values and measurement regions |
| 投稿时间：2008-11-19 修订日期：2009-01-06 |
| DOI： |
| 中文关键词: 肝肿瘤 扩散加权成像 鉴别诊断 |
| 英文关键词:Liver neoplasms Diffusion weighted imaging Diagnosis, differential |
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| 中文摘要: |
| 目的 探讨利用不同b值和测量位置得到的表观扩散系数(ADC)值、指数化表观扩散系数(eADC)值以及灌注ADC和eADC值在肝脏良、恶性病变鉴别诊断中的价值。方法 分别对41例肝脏良性病变和62例恶性病变行磁共振扩散加权成像(DWI)扫描,并计算低(100、200和300 s/mm2)、中(400和600 s/mm2)和高(800、1000和1200 s/mm2)b值时病灶整体、边缘及中心的ADC值和eADC值,然后根据低、高b值时ADC和eADC值的差异计算灌注ADC和eADC值。分析不同b值时各测量参数在良、恶性病变之间以及病灶边缘与中心之间的差异。结果 良、恶性病变之间,低b值ADC值及eADC值差异均无统计学意义(P＞0.05);中b值时病灶整体及中心ADC及eADC值差异均有统计学意义(P<0.05);高b值时,病灶整体及边缘、中心的ADC值和eADC值差异亦有统计学意义(P<0.05)。另外,病灶整体及边缘、中心的灌注ADC值和eADC值差异也有统计学意义(P<0.05)。对于不同的测量感兴趣区位置而言,在病灶边缘与中心之间,恶性病变的灌注ADC值及eADC值差异有统计学意义(P<0.05),但良性病变差异无统计学意义(P＞0.05)。结论 高b值时测量区域在肝脏病灶边缘得到的DWI测量值更加准确,灌注ADC值和eADC值是鉴别肝脏良、恶性病灶的可靠指标。 |
| 英文摘要: |
| Objective To observe the significance of the apparent diffusion coefficient (ADC) value, exponential apparent diffusion coefficient (eADC) value, perfusion ADC (ADCperf) and perfusion eADC (eADCperf) values of MR diffusion weighted imaging (DWI) in differential diagnosis of benign and malignant liver lesions with different b values and measurement regions. Methods DWI scan was performed on 41 patients with benign liver lesions and 62 patients with malignant liver tumors. The ADC value and eADC value with low (100, 200 and 300 s/mm2), moderate (400 and 600 s/mm2) and high (800, 1000 and 1200 s/mm2) b values were analyzed on the entire lesions, margins and center regions. The differences in ADC and eADC values between low and high b value, ADCperf and eADCperf value were calculated. The differences of all measured parameters with different b values between benign and malignant groups and between lesion margins and center regions were analyzed. Results Between benign and malignant lesions, no difference in ADC or eADC value with low b value was found (P＞0.05), whereas the differences in both values of the entire lesion and center with moderate b value were identified (P<0.05). The differences in both values with high b value and in ADC and eADC values of the entire lesion and margins and center regions had statistical significance (P<0.05), so as the differences in ADCperf and eADCperf values of entire lesion, margins and center regions (P<0.05). Besides, the differences in ADCperf and eADCperf values of malignant lesions between lesion margins and center were also detected (P<0.05), but not for benign ones (P＞0.05). Conclusion The measurement parameters of DWI are accurate when the measured region is set on lesion margins with high b value, and the ADCperf and eADCperf are reliable indexes in differential diagnosis of benign and malignant liver lesions. |
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