| 牟宗霞,侯文生,郑小林,吴小鹰,沈珊,Annette M Sterr,彭承琳.视觉反馈增益对力量输出影响的fMRI研究[J].中国医学影像技术,2009,25(5):749~752 |
| 视觉反馈增益对力量输出影响的fMRI研究 |
| fMRI observation of the effect of visual feedback gain on force production |
| 投稿时间：2008-05-04 修订日期：2009-02-20 |
| DOI： |
| 中文关键词: 视觉反馈 磁共振成像 增益 运动皮层 |
| 英文关键词:Visual feedback Magnetic resonance imaging Gain Motor cortex |
| 基金项目:国家自然科学基金(30770546)、重庆市自然科学基金(2006BB2043和2007BB5148)。 |
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| 中文摘要: |
| 目的 运用全脑fMRI技术研究视觉反馈增益在运动功能执行中的调节作用。方法 设计快、慢两种变化速度的力量跟踪任务,在高低不同的两种视觉反馈增益下令15名正常受试者做右手握力运动,同时接受BOLD-fMRI扫描;采用t检验分析获得不同运动状态与静息状态信号对比的脑功能图,对比观察脑皮层兴奋区的异同。结果 四种模式握力运动均可激活初级躯体感觉运动区(SMC)、双侧前运动区(PMC)、辅助运动区(SMA)、小脑、基底节(BG)和对侧后顶叶(PPC)等。随着反馈增益的提高:S1、PPC、PMC、小脑等激活强度、范围均降低,BG恰好相反;SMA激活强度提高但范围缩小,M1表现不明显。结论 视觉反馈增益对力量输出有显著影响,不同增益所激活的脑区不同。PPC、PMC、小脑、基底节等参与调节过程。 |
| 英文摘要: |
| Objective To study the effect of visual feedback gain on movement with the whole-brain functional magnetic resonance imaging (fMRI). Methods Fifteen healthy volunteers were recruited to execute a grasping task with right hand, and two force track tasks with different increasing/decreasing force rate were performed. The activated areas were evaluated with BOLD fMRI, and functional responses were established by student's group t test analysis. Results All four different grasping tasks could activate the primary somatosensory cortex (SMC), bilateral pre-motor area (PMC), supplementary motor area (SMA), cerebellum, basal ganglia (BG), the contralateral posterior parietal cortex (PPC), etc. With the increase of feedback-dependent BOLD signal, both the size and the intensity decreased in S1, PPC, PMC and cerebellum, while the activation of BG was opposite. The intensity of the active area in SMA swelled while the extent decreased, and no significant difference was found in the M1. Conclusion Visual stimuli can influence force output significantly and different visual feedback gains may recruit different cortex function areas to execute different motor tasks. PPC, PMC, cerebellum and BG participate in regulating the power of the hand grasp with different gains. |
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