| 姚建,桂维玲.超顺磁性Fe2O3用作磁共振胃肠对比剂[J].中国医学影像技术,2009,25(4):695~697 |
| 超顺磁性Fe2O3用作磁共振胃肠对比剂 |
| Superparamagnetic Fe2O3 microparticles as gastrointestinal contrast agent in magnetic resonance imaging |
| 投稿时间：2008-05-28 修订日期：2008-12-30 |
| DOI： |
| 中文关键词: 超顺磁性 对比剂 磁共振成像 三氧化二铁 稳定悬浮性 |
| 英文关键词:Superparamagnetic Contrast media Magnetic resonance imaging Fe2O3 Suspension stability |
| 基金项目:山东省科技厅计划项目(003130103),山东省教育厅科技计划项目(JOOK51)。 |
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| 中文摘要: |
| 目的 制备一种由Fe2O3为主要原料的口服磁共振胃肠造影混悬剂,研究Fe2O3在磁共振磁场中保持超顺磁性和稳定悬浮的临界尺寸。方法 根据超顺磁性理论,推导出Fe2O3微粒显示超顺磁现象的临界尺寸理论值和在1.5T磁共振磁场中的临界值;根据磁学理论,分析磁共振对比剂稳定的机制,推导在磁共振磁场中,Fe2O3微粒在对比剂中稳定悬浮的极限尺寸。以小于该尺寸的Fe2O3微粒作主料制备对比剂,并进行磁共振成像对比增强实验研究。结果 在1.5T磁共振磁场中, Fe2O3微粒在对比剂中既能稳定悬浮又具有超顺磁性的极限尺寸为11.1 nm,Fe3O4为7.1 nm。用尺寸为10 nm 的Fe2O3微粒制备的对比剂,具有稳定、超顺磁性、安全、不沉降、不团聚的特性,且在磁共振成像上呈现明显的阴性对比作用。结论 从微粒尺寸角度考虑,用Fe2O3微粒作对比剂中的磁性粒子比Fe3O4更有优势。 |
| 英文摘要: |
| Objective To make a kind of oral gastrointestinal contrast agent mainly from Fe2O3, and to study its critical size of suspension stability and superparamagnetism in MR magnetic field. Methods The critical size in 1.5T magnetic field was deduced according to superparamagnetic theory. The mechanism of suspension stability and the critical size were analyzed based on magnetic theory. Contrast agent was made with Fe2O3 as the major material and MRI relaxation enhancement of the contrast agent was studied. Results The proper limit size for Fe2O3 suspension stability and superparamagnetism in the contrast agent was 11.1 nm, while the proper limit size for Fe3O4 was 7.1 nm. Cnotrast agent made from microparticle with mean diameter of 10 nm had features of stability, settlement and superparamagnetism without obvious toxicity nor agglomeration. Conclusion Fe2O3 microparticles used as the major materials in magnetic resonance imaging is better than that with Fe3O4 microparticles. |
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