| 郭雪梅,王霄英,吴冰,蒋学祥.前列腺外周带癌的ADC值与其病理分级和临床分期的相关性[J].中国医学影像技术,2009,25(4):674~677 |
| 前列腺外周带癌的ADC值与其病理分级和临床分期的相关性 |
| Correlation of ADC value with Gleason score and clinical staging of peripheral zone prostate cancer |
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| DOI： |
| 中文关键词: 前列腺肿瘤 磁共振成像 扩散加权成像 Gleason评分 |
| 英文关键词:Prostatic neoplasms Magnetic resonance imaging Diffusion weighted imaging Gleason score |
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| 中文摘要: |
| 目的 研究磁共振扩散加权成像所得ADC值与前列腺癌病理分级和临床分期之间的关系。方法 使用1.5T MR扫描仪对40例经穿刺活检病理证实的前列腺癌患者行DWI扫描,b值采用0和800 s/mm2。以六分区法为基础,根据穿刺活检结果,将每一扫描层面内两侧外周带归为非癌区或癌区。获得外周带各分区的分区内最小ADC值。将每个病例的ADC值与穿刺活检所得的Gleason评分及临床分期情况进行比较、分析。结果 癌区平均ADC值为(1.01±0.27)×10-3 mm2 /s,ADC值与Gleason评分及临床分期之间均具有负相关性,中分化癌灶的ADC值明显高于低分化癌灶,限局性癌灶的ADC值明显高于进展期癌灶。以分区内最小ADC值1.03×10-3 mm2 /s为临界点,区分中分化与低分化癌灶的诊断敏感性71.43％,特异性63.79％,准确性65.57％。以分区内最小ADC值1.09×10-3 mm2 /s为临界点,区分限局性与进展性癌灶的诊断敏感性75.02％,特异性78.63％,准确性77.21％。结论 前列腺外周带癌的ADC值与病理分级及临床分期之间具有一定相关性,有预测癌灶恶性程度的潜力。 |
| 英文摘要: |
| Objective To evaluate the correlation between ADC value of diffusion weighted imaging with the Gleason score and clinical staging of the peripheral zone prostate cancer. Methods Forty patients with peripheral zone prostate cancer proved by ultrasound guided systemic biopsy underwent MR scan with b value of 0 and 800 s/mm2. The peripheral zones of prostate were divided into six areas by location and were attributed to noncancerous and cancerous areas according to the results of biopsy. The ADC value of each peripheral cancerous zone was recorded and analyzed. Results The mean ADC of cancerous zone was (1.01±0.27)×10-3 mm2 /s. The ADC value was negtively correlated with the Gleason score and the clinical staging. The ADC value of the medium grade cancer was higher than that of the low grade cancer, while of the confined cancer was higher than that of the advanced cancer. The sensitivity of differentiating the medium and low grade cancer was 71.43%, and the specificity was 63.79%, the accuracy was 65.57%, with the cutoff point 1.03×10-3 mm2 /s. The sensitivity of differentiating the stage B from stage C, D cancer was 75.02%, and the specificity was 78.63%, the accuracy was 77.21%, with the cutoff point 1.09×10-3 mm2 /s. Conclusion There is certain correlation between the ADC value of peripheral zone prostate cancer with the Gleason score and the clinical staging. ADC value has the potential of forecasting the malignancy of the peripheral zone prostate cancer. |
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