| 万娅敏,高剑波,周志刚,周建中,王振豫.放射性粒子125I联合化学性粒子中人氟安治疗非小细胞肺癌[J].中国医学影像技术,2009,25(3):482~484 |
| 放射性粒子125I联合化学性粒子中人氟安治疗非小细胞肺癌 |
| Interstitial implantation of radioactive seeds 125I combined with chemical sinofuan for the therapy of non-small cell lung cancer |
| 投稿时间：2008-09-22 修订日期：2008-10-18 |
| DOI： |
| 中文关键词: 肺肿瘤 125I 化疗粒子 |
| 英文关键词:Lung neoplasms Iodineradioisotopes Fluorouracil sustained release |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨放射性125I粒子联合化学性粒子组织间植入治疗非小细胞癌(NSCLS)的疗效。方法 在CT引导下对45例NSCLC患者行肿瘤内125I联合化学性粒子中人氟安植入治疗,粒子植入之前采用TPS模拟布源求出术中所需粒子的总活度及数量。粒子植入后2个月复查CT,分析病灶缓解情况及其和病理分级的关系。结果 2个月后CT复查,完全缓解(CR)12例,部分缓解(PR)28例,无变化(NC)3例,进展(PD)2例。总有效率88.89%。疗效和病理分级有关。结论 125I放射性粒子联合化学性粒子植入治疗NSCLC癌疗效确切,创伤小且并发症少。 |
| 英文摘要: |
| Objective To assess the value of interstitial implantation of radioactive seeds 125I combined with chemical sinofuan for the therapy of NSCLC. Methods A total of 45 patients with NSCLC were treated by CT guided radioactive seeds and chemical sinofuan interstitial implantation according to the treatment planning system (TPS) and were exammed with CT after 2 months to observe the remission and the relation with the the grades of cancer cell. Results Two months after implantation, CT examination showed complete remission in 12 patients, partial remission in 28 patients, no change in 3 patients and progressive disease in 2 patients. The response rate was 88.89%. Therapeutic effect was associated with the grades of cancer cell. Conclusion CT guided 125I and chemical sinofuan seeds implantion is an effective, microinvasive method with few complications for the treatment of NSCLC. |
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