| 庞彩霞,李智贤,丁雪明,张莉,韦康来,黄克强.乳腺浸润性导管癌:超声征象与ER、C-erbB-2表达的关系[J].中国医学影像技术,2009,25(3):449~452 |
| 乳腺浸润性导管癌:超声征象与ER、C-erbB-2表达的关系 |
| Infiltrating ductal cancer of breast: correlation between ultrasonographic features and ER, C-erbB-2 expression level |
| 投稿时间：2008-10-10 修订日期：2008-12-15 |
| DOI： |
| 中文关键词: 超声检查 乳腺浸润性导管癌 雌激素受体 人表皮生长因子受体-2 |
| 英文关键词:Ultrasonography Breast infiltrating ductal carcinoma Estrogen receptor Human epidermal growth factor receptor 2 |
| 基金项目:国家"十一五"科技支撑计划项目基金(2007BAI07A17-11)。 |
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| 中文摘要: |
| 目的 探讨乳腺浸润性导管癌(IDC)超声征象和雌激素受体(ER)、人表皮生长因子受体-2 (C-erbB-2)之间的关系。方法 将207例经手术病理证实的IDC的主要超声表现与术后标本免疫组织化学染色评价的ER、C-erbB-2表达情况进行对照分析。结果 ①在207例IDC中,ER阳性率为57.97%(120/207),超声显示肿块有边缘毛刺征、后方声衰减者肿块ER阳性率高于不具有上述征象者(P<0.05); ② C-erbB-2过表达率为29.95%(62/207),有微钙化征象者肿块C-erbB-2过表达率高于无微钙化征象者(P<0.05)。结论 IDC的主要超声征象中的边缘毛刺征、后方声衰减可在一定程度上预测肿块ER的表达水平;微钙化征象可在一定程度上预测肿块C-erbB-2的过表达水平。 |
| 英文摘要: |
| Objective To probe the relationship between the appearance on ultrasonic sign and estrogen receptor (ER), C-erbB-2 in infiltrating ductal carcinoma of breast (IDC), and to evaluate the possibility of predicting the expression of ER and C-erbB-2 in IDC preoperation by means of ultrasonography. Methods A total of 207 patients with IDC confirmed pathologically were involved in this study. ER and C-erbB-2 expression of the mastectomy specimens was determined with immunohistochemical staining technique. The correlation between the ultrasonographic features and ER, C-erbB-2 positive expression was analyzed. Results ①Of 207 cases, the ER positive rate was 57.97% (120/207). ER positive rate in lesions with spicule sign or posterior shadowing attenuation of the ultrasonography was higher than that in lesions without the certain ultrasonographic features (P<0.05). ②Of 207 cases, the C-erbB-2 over expressive rate was 29.95% (62/207), and the C-erbB-2 over expressive rate in lesions with the microcalcifications of the ultrasonography was higher than that in lesions without microcalcifications (P<0.05). Conclusion The spicule sign and posterior shadowing attenuation of the ultrasonography have certain correlation with ER expression in patients with IDC, while the microcalcifications have certain correlation with C-erbB-2 over expression . |
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