陈宇,吴明祥,徐坚民,冯敢生,孙国平,龚静山,李莹,张景中,朱进.DTI纤维追踪法定量分析90名正常国人脑白质老化[J].中国医学影像技术,2009,25(3):369~372
DTI纤维追踪法定量分析90名正常国人脑白质老化
White matter fiber tracking method for the study of aging-quantitative diffusion tensor imaging analysis of ninety healthy adult Chinese
投稿时间:2008-08-01  修订日期:2008-12-26
DOI:
中文关键词:  脑白质  磁共振成像  扩散张量成像  相对各向异性  纤维追踪法
英文关键词:Brain white matter  Magnetic resonance imaging  Diffusion tensor imaging  Fractional anisotropy  Fiber tracking
基金项目:2006年深圳市卫生局科技重点项目(200604)。
作者单位E-mail
陈宇 华中科技大学同济医学院附属协和医院放射科,湖北 武汉 430022
深圳市人民医院放射科,广东 深圳 518020 
 
吴明祥 深圳市人民医院放射科,广东 深圳 518020  
徐坚民 深圳市人民医院放射科,广东 深圳 518020 xjmxxs@21cn.com 
冯敢生 华中科技大学同济医学院附属协和医院放射科,湖北 武汉 430022  
孙国平 深圳市人民医院放射科,广东 深圳 518020  
龚静山 深圳市人民医院放射科,广东 深圳 518020  
李莹 深圳市人民医院放射科,广东 深圳 518020  
张景中 深圳市人民医院放射科,广东 深圳 518020  
朱进 深圳市人民医院放射科,广东 深圳 518020  
摘要点击次数: 2423
全文下载次数: 1108
中文摘要:
       目的 采用DTI纤维追踪法定量比较不同年龄组正常自愿者椎体束从大脑脚到中央前回部分(PRPT)FA值的差别及其意义。方法 将90名正常志愿者按年龄分为6组,进行基于纤维追踪的定量DTI研究,图像标准化后分析各组PRPT的FA值与年龄组老化的关系。结果 各年龄组双侧PRPT的FA值分布相似,最低点在放射冠处,最高峰为内囊后肢;各段FA值随年龄增长呈下降趋势,表明这些部位的纤维随年龄增长发生了老化,其中以额叶老化最为明显;并发现额叶及大脑脚白质老化过程中存在突然变化。结论 DTI可以作为评价脑组织细微结构变化和老化过程的敏感工具;额叶及大脑脚白质老化过程中存在突变是否为脑生理上老化的标志有待进一步研究。
英文摘要:
      Objective To investigate the difference and significance of fractional anisotropy (FA) of precentral portion of the pyramidal tract (PRPT, from cerebral peduncle to precentral gyrus) in different age-groups healthy volunteers using quantitative diffusion tensor imaging (DTI) based on fiber tractography. Methods Quantitative DTI based on fiber tractography was performed in 90 healthy volunteers (20-83 years, divided into 6 age groups) at a 1.5T MR scanner. Standardized images data was analyzed for the relationship between FA values of PRPT and aging. Results The FA value of bilateral PRPT in each age group distributed similarly, in which FA value of corona radiata was the lowest and the posterior limb of the internal capsule was the highest. The FA values of sections were declining with aging, the fibers of these parts had significantly aging, and the most obvious aging part was the frontal lobe. The procedure of aging in the frontal lobe and cerebral peduncle existed mutation period. Conclusion DTI is a sensitive method for detecting the microstructural changes and aging process of brain white matter. Whether the mutation of aging in the frontal lobe and cerebral peduncle is the physical signs of aging should be further examined.
查看全文  查看/发表评论  下载PDF阅读器