| 刘佳,沈加林,许建荣,周滟,路青.磁共振波谱对特发性震颤的病因学观察[J].中国医学影像技术,2009,25(3):366~368 |
| 磁共振波谱对特发性震颤的病因学观察 |
| MRS observation on etiology of essential tremor |
| 投稿时间：2008-07-03 修订日期：2008-12-22 |
| DOI： |
| 中文关键词: 特发性震颤 磁共振波谱 小脑皮质 |
| 英文关键词:Essential tremor Magnetic resonance spectroscopy Cerebellar cortex |
| 基金项目: |
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| 中文摘要: |
| 目的 用磁共振波谱(MRS)观察特发性震颤(ET)患者小脑皮质代谢物变化情况。方法 ET患者11例为病例组,健康人7名为对照组,对双侧小脑皮质进行磁共振波谱(MRS)检查,计算乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)比值,并对每例患者进行临床评分(Fahn-Tolosa-Marin)。结果 病例组同侧小脑皮质NAA/Cr较对照组减低(0.78±0.05,0.90±0.16;P=0.03)。病例组双侧小脑皮质代谢物比值与症状评分间无明显相关性。结论 ET患者小脑皮质存在神经元的损伤或丢失,提示ET很可能是一种神经退行性疾病。 |
| 英文摘要: |
| Objective To investigate the metabolic alterations in the cerebellar cortex of patients with essential tremor (ET) using magnetic resonance spectroscopy (MRS). Methods Eleven ET patients and 7 healthy controls underwent 1H-MRS examination to measure levels of intracellular metabolites, including ratio of N-acetyll-aspartate (NAA) and total choline (Cho) to total creatine (Cr) in cerebellar cortex with a 3.0T Philips Achieva System. Results The mean (standard deviation) ipsilateral cerebellar cortical NAA/Cr decreased in ET patients compared with controls (0.78±0.05 vs 0.90±0.16, P=0.03). There was no relationship between cerebellar cortical NAA/Cr and dominant arm tremor severity (P>0.05). Conclusion The reduction in cerebellar cortical NAA/Cr indicates that there is neuronal damage or loss in ET, suggesting that ET may be a neurodegenerative disease. |
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