| 马树华,乐洪波,廖玲敏,王兆新,张文校,程晓玲,贾宝辉,黄宝俊,李玉光.安非他明成瘾患者情绪损伤的脑功能磁共振成像研究[J].中国医学影像技术,2009,25(2):207~210 |
| 安非他明成瘾患者情绪损伤的脑功能磁共振成像研究 |
| Emotional abnormality in Amphetamine addicts: an fMRI study |
| 投稿时间：2008-08-11 修订日期：2008-09-17 |
| DOI： |
| 中文关键词: 安非他明相关性障碍 脑 磁共振成像 情绪 |
| 英文关键词:Amphetamine-related disorders Brain Magnetic resonance imaging Emotion |
| 基金项目:北京市自然基金重点项目(4061004)。 |
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| 中文摘要: |
| 目的 探讨安非他明成瘾患者情绪损伤特殊脑区的激活。方法 通过功能磁共振成像,采用统计参数图软件(SPM2)处理,t检验进行统计学分析,以像素强度阈值 的像素构成统计参数图,探讨12例安非他明成瘾患者和12例健康受试者观看安非他明、悲哀、喜悦线索图片时的脑区的激活情况。结果 安非他明成瘾患者在观看安非他明线索图片时,前扣带回表现出显著激活(tmax = 11.7,P<0.001),观看高兴、悲哀线索图片时前扣带回无显著激活(P＞0.05);健康受试者在观看各类线索图片时,前扣带回均无显著激活(P＞0.05)。在观看高兴、悲哀图片时,安非他明成瘾患者额叶的部分区域激活弱于健康受试者 (P＞0.05)。结论 安非他明成瘾患者有较广泛的情绪损伤。 |
| 英文摘要: |
| Objective To investigate the octivations of specific encephalic zone of emotional Abnormality in amphetamine addicts. Methods Brain activity was measured in 12 amphetamine addicts and 12 healthy subjects while watching pictures designed to elicit happy feelings, sad feelings, or the desire to use Amphetamine with functional magnetic resonance imaging (fMRI). Results The Amphetamine addicts watching Amphetamine-cue images had significant regional brain activations in anterior cingulate cortex (tmax =11.7, P＜0.001), while no significant regional brain activations were detected in Amphetamine addicts watching images that evoked happy or sad feelings (P＞0.05). The Amphetamine addicts watching happy or sad images had fewer significant regional activation of brain than that of the healthy subjects. Conclusion Amphetamine addicts have abnormalities in affect-related brain activation. |
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