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吴凤芸,张宇虹,苏本利.高频超声评价2型糖尿病患者颈动脉粥样硬化血管重构[J].中国医学影像技术,2009,25(1):65~68

高频超声评价2型糖尿病患者颈动脉粥样硬化血管重构

Study on remodeling of carotid atherosclerosis in patients of type 2 diabetes mellitus with high-frequency ultrasound

投稿时间：2008-10-09 修订日期：2008-11-09

DOI：

中文关键词: 颈动脉动脉粥样硬化糖尿病超声检查

英文关键词:Carotid arteries Atherosclerosis Diabetes mellitus Ultrasonography

基金项目:

作者	单位	E-mail
吴凤芸	大连医科大学附属第二医院超声科,辽宁大连 116027
张宇虹	大连医科大学附属第二医院超声科,辽宁大连 116027	zhangyh_66@yahoo.com.cn
苏本利	大连医科大学附属第二医院内分泌科,辽宁大连 116027

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中文摘要:

目的应用高频超声评价2型糖尿病患者(T₂DM)颈动脉粥样硬化血管重构及其临床价值。方法将100例T₂DM患者按病程分为3组:病程小于5年为A组(36例);5~10年为B组(31例);大于10年为C组(33例);正常对照组为D组(30例)。应用高频超声观察颈动脉内-中膜厚度(IMT),如有斑块形成,测量其血管总面积(TVA)、管腔面积(LA)、斑块面积(PA)、重构指数(RI),并检测血清胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、载脂蛋白A₁ (ApoA₁)、载脂蛋白B(ApoB)。结果糖尿病各组颈动脉血管重构发生率高于对照组(P<0.05);C组血管重构发生率高于A、B组(P<0.05);C组血管负性重构发生率高于正性重构发生率(P<0.05);A、B组血管正性重构发生率高于负性重构发生率(P<0.05);C组中软斑及混合斑的血管负性重构发生率高于A、B、D组(P<0.05);软斑、硬斑及混合斑之间重构发生率差异无统计学意义(P>0.05);软斑组的血管正性重构发生率、TC、LDL-C及ApoB高于硬斑组及混合斑组(P<0.05)。结论应用高频超声能够简便、准确、综合地评价2型糖尿病患者颈动脉粥样硬化血管重构。

英文摘要:

Objective To study the remodeling of carotid atherosclerosis and its clinical value in patients of type 2 diabetes mellitus (T2DM ) by high-frequency ultrasound. Methods One hundred patients of T₂DM and 30 healthy controls were examined by high-frequency ultrasound. The patients of T₂DM were devidied into 3 groups (A, B, C) by the course of disease. The intimal-medial thickness (IMT), total vessel area (TVA), plaque area (PA), lumen area (LA) and remodeling index (RI) were calculated at atherosclerotic lesion segments. Total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), apolipoprotein A₁ (ApoA₁) and apolipoprotein B (ApoB) were measured. Results The rate of remodeling of carotid atherosclerosis in type 2 diabetes mellitus was higher than that of the control group (P<0.05). The rate of remodeling in group C was higher than that of group A and B (P<0.05). The rate of negative remodeling was higher than that of positive remodeling in group C (P<0.05). The rate of positive remodeling was higher than that of negative remodeling in group A and B (P<0.05). The rate of negative remodeling of soft and mixed plaques in group C was higher than that in group A, B and D (P<0.05). There was no significant difference in rate of remodeling among soft, hard and mixied plaques (P>0.05). The rates of positive remodeling, TC, LDL-C and ApoB were higher in soft plaques than those in hard and mixed plaques (P<0.05). Conclusion High-frequency ultrasound is a convenient, precise and integrated method to assess remodeling of carotid atherosclerosis in the patients of T₂DM.

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