| 高宙,胡疏,陈清,贾少微.多动症伴学习困难患儿SPECT显像特点及临床应用[J].中国医学影像技术,2008,24(s1):197~198 |
| 多动症伴学习困难患儿SPECT显像特点及临床应用 |
| Characteristic and clinical application of SPECT imaging in ADHD children with learning difficulties |
| 投稿时间：2008-05-05 修订日期：2008-07-28 |
| DOI： |
| 中文关键词: 多动症 单光子发射计算机断层扫描 脑灌注显像 |
| 英文关键词:Attention deficit and hyperactive disorder Single photon emission computed tomography CBF imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 利用单光子发射计算机断层扫描(SPECT)脑灌注显像技术,观察多动症同时伴有学习困难患儿的局部脑血流灌注量的改变情况,探讨多动症同时伴有学习困难儿童局部脑功能状态和易损部位及特点。方法 对60例符合美国DSM-Ⅳ诊断标准的多动症患儿同时伴有学习困难者进行SPECT 99mTc-ECD脑灌注显像检查,并对此类患儿局部脑功能状态和易损部位进行统计学分析。结果 60例多动症患儿SPECT检查中发现大脑皮质不同的功能区均有不同程度的血流灌注 |
| 英文摘要: |
| Objective To observe the change of regional cerebral blood flow in ADHD children with learning difficulties by single photon emission computed tomography (SPECT) brain perfusion imaging, so as to explore regional cerebral functional activity, damageable zone and characteristics of those children. Methods SPECT 99mTc-ECD brain perfusion imaging were performed in 60 subjects that American DSM-IV classification and diagnostic criteria for ADHD children with learning difficulties, and carry out statistical analysis of regional cerebral functional activity and damageable zone for such children. Results Among 60 ADHD children, SPECT examination found that the cerebral cortex of different functional areas had different degrees of abnormality of blood flow perfusion, the frontal lobe and basal ganglia damage are the most common. Among which, 49 cases (81.7%), bilateral basal ganglia blood flow perfusion and function did not match; 53 cases (88.3%) unilateral or bilateral frontal lobe blood flow perfusion had decreased, among which, left prefrontal blood flow decreased was 45 cases, right prefrontal is 39 cases. Temporal lobe blood flow dropped is 21 cases (35%), occipital lobe is 14 cases (23.3%) and parietal lobe is 3 cases (5%). Conclusion ADHD children with learning difficulties not only have psychological and behavioral abnormalities, but also have damage in cerebral function and blood flow perfusion. The abnormality of cerebral blood flow and function in brain perfusion imaging are most likely to appear in the frontal lobe and the basal ganglia, followed by the temporal lobe, occipital and parietal lobe. SPECT brain perfusion imaging technology can be intuitive, accurate for understanding of attention deficit hyperactivity disorder children with learning difficulties, whether the cerebral substance is damage and where the impaired functional area is, provide the basis and guidance for clinical treatment. |
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