| 卫春芳,胡兵,姜立新.高强度聚焦超声消融离体人子宫腺肌病标本[J].中国医学影像技术,2008,24(12):1897~1900 |
| 高强度聚焦超声消融离体人子宫腺肌病标本 |
| High intensity focused ultrasound ablation for human adenomyosis in vitro |
| 投稿时间：2008-05-04 修订日期：2008-11-04 |
| DOI： |
| 中文关键词: 子宫内膜异位症 离体 高强度聚焦超声 |
| 英文关键词:Endometriosis In vitro High intensity focused ultrasound |
| 基金项目: |
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| 摘要点击次数: 2076 |
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| 中文摘要: |
| 目的 探讨高强度聚焦超声(HIFU)消融离体人子宫腺肌病标本的有效性和临床可行性。方法 对手术切除的新鲜人子宫腺肌病标本7件进行HIFU消融。照射完毕后超声测量照射区域的最大截面积。取材后将标本进行2,3,5-三苯基氯化四氮唑(TTC)染色,测量未着色区最大截面积,并将两种方法测量的结果进行比较。组织病理学检查观察照射区域及周围组织的细胞形态学改变。结果 照射前子宫腺肌病标本病灶区域呈不均匀较低回声,照射后该区域回声明显增强。肉眼观察见照射区域周围组织未见明显改变,照射区域内组织呈灰黄色,质地变坚硬,TTC染色显示该区域内未着色,与周围组织边界清晰。声像图上高回声区最大截面积与TTC染色未着色区域最大截面积差异无统计学意义(P＞0.05)。结论 HIFU能有效形成消融灶,且对周围组织无损伤。 |
| 英文摘要: |
| Objective To investigate the efficacy and clinical feasibility of high intensity focused ultrasound (HIFU) ablation for the human adenomyosis in vitro. Methods Seven human adenomyosis specimens were ablated with HIFU, and maximal ranges of hyperecho in ablated masses were detected with sonography. Then the specimens were stained in TTC (2,3,5-Triphenyltetrazolium chloride) solution, and maximal ranges were measured where TTC staining was negative. The results obtained by two methods were compared. At last, the tissues and cells in and around the ablated masses were observed under light microscope. Results The regions of adenomyosis in the specimens were hypoechoic heterogeneously with sonography before ablation, and the hyperechoic regions were detected in all ablated areas. The ablated regions in the specimens became gray-yellow and hardened, while the regions out of the ablation had no obvious change with eyes. The TTC staining was negative in the ablated lesion where histological examination revealed coagulation necrosis and the stained regions had no obvious change in histology. There was no difference between the two average maximal ablated ranges (P>0.05). Conclusion HIFU can ablate human adenomyosis in vitro effectively and do not hurt the tissues around of the ablation. |
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