| 汪俊萍,白人驹,孙浩然,赵新,李亚军,杨晶.兔VX2种植性肝癌模型不同生长期的常规MR和扩散加权成像与病理对照[J].中国医学影像技术,2008,24(12):1889~1892 |
| 兔VX2种植性肝癌模型不同生长期的常规MR和扩散加权成像与病理对照 |
| Conventional MR series and diffusion weighted imaging of rabbit liver VX2 tumor models in different periods |
| 投稿时间：2008-06-20 修订日期：2008-09-27 |
| DOI： |
| 中文关键词: 肝脏 模型,动物 扩散加权磁共振成像 |
| 英文关键词:Liver Models, animal Diffusion magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 初步探讨DWI对监测兔VX2种植性肝癌模型生长特点的价值。方法 新西兰大白兔44只,采用开腹下瘤组织块穿刺接种法,每只实验兔接种1个部位,将成功建立模型的38只实验兔随机分为两组(14 d组和22 d组),分别在规定的时间内行常规MR序列和DWI检查(b=1000 s/mm2),分别获得不同时间点肿瘤的ADC图,并对全部肿瘤标本按扫描方向切层并行大体病理检查。结果 ①两组肿瘤在DWI上均呈明显高信号,与周围肝实质形成鲜明对比;②14 d组所有肿瘤的ADC图信号均匀,大体病理显示所有肿瘤质地均匀,无坏死囊变区,与ADC图表现一致;22 d组所有肿瘤中心部分在ADC图上均可见斑片状坏死囊变区的信号,且与大体病理所显示的范围基本一致,而在常规T2WI上仅有4例肿瘤中心可见斑片状高信号。结论 DWI检查的ADC图可敏感检出肿瘤的坏死囊变区,在动态追踪肿瘤发生、发展和生长特性方面具有重要的价值,是常规MR检查的有益补充。 |
| 英文摘要: |
| Objective To initially explore the value of DWI for monitoring the growth characteristics of rabbit models of liver VX2 tumor. Methods Forty-four New Zealand white rabbits were enrolled, and VX2 tumor tissues were implanted into the left liver lobes after laparotomy. The 38 successfully implanted rabbits assigned randomly into 2 equal groups underwent conventional MR series and DWI (b value is 1000 s/mm2) in different periods (14 d and 22 d) after implantation respectively, and ADC maps were obtained. Gross specimens of livers of all rabbits were sliced according to the direction of MR scanning rightly after MR examination. Results All tumors of both groups showed obviously high signal intensity on DWI. On ADC maps, all tumors in the group of 14 d showed homogeneously signal intensity and demonstrated well distributed texture without cystic necrosis according to pathology. However,on ADC maps, the central parts of all tumors in the group of 22 d showed the signal intensity of cystic necrosis,whose scopes were equal to that of specimen of gross pathology, while on T2WI only the central parts of 4 tumors showed patchy high signal intensity. Conclusion ADC map can monitor the cystic necrosis areas of the tumor on early stage, playing important value in dynamic detection of genesis and development of the tumor and the growth characteristics of rabbit liver VX2 tumor models. |
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