| 张洁,于铁链,吴琦,叶宁,曹杨,张静,周宁.多层螺旋CT定量研究慢性阻塞性肺疾病肺衰减值[J].中国医学影像技术,2008,24(10):1611~1614 |
| 多层螺旋CT定量研究慢性阻塞性肺疾病肺衰减值 |
| Quantitative MSCT study of lung attenuation in patients with chronic obstructive pulmonary disease |
| 投稿时间：2008-04-22 修订日期：2008-07-28 |
| DOI： |
| 中文关键词: 肺气肿 肺疾病,慢性阻塞性 体层摄影技术,X线计算机 |
| 英文关键词:Emphysema Pulmonary disease, chronic obstructive Tomography, X-ray computed |
| 基金项目: |
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| 中文摘要: |
| 目的 应用16层螺旋CT扫描观察慢性阻塞性肺疾病 (COPD) 患者肺衰减值与肺功能检查结果的相关关系。方法 COPD患者共50例,均行16层螺旋CT检查和肺功能检查。通过直方图技术测量全肺平均衰减值(MLA)、小于－910 HU和小于－950 HU阈值的像素指数(PI-910、PI-950),评估MLA、PI-910及PI-950与肺功能检查结果间的相关关系,并比较COPD 0~4级组间MLA、PI-910及PI-950的组间差异。结果 MLA、PI-910及PI-950与肺功能指标间均存在相关关系,与反映存在气流受限的指标FEV 1%FVC(%)相关关系最强,PI-950与肺功能检查结果间的相关关系较MLA、PI-910强。PI-950较MLA、PI-910更能反映组间差异。结论 CT定量研究COPD肺衰减值可对患者肺实质改变进行全肺三维立体评估。PI-950可作为CT定量评估COPD患者肺实质改变较敏感的指标。 |
| 英文摘要: |
| Objective To investigate the relationship between lung attenuation and pulmonary function test (PFT) results in patients with COPD using 16-slice spiral CT (16-SCT). Methods Fifty COPD patients underwent 16-SCT and PFT. Quantitative analysis was performed with histograms, and the mean lung attenuation (MLA), the pixel index (PI) of the proportions of lung volumes with attention values below －910 HU and －950 HU were measured. The correlations between MSCT measurements and PFT results were assessed, and differences of MLA, PI-910 and PI-950 among the groups of the patients with COPD from stage 0-4 were evaluated. Results MLA, PI-910 and PI-950 were significantly correlated with PFT results. MLA, PI-910 and PI-950 correlated the most closely with FEV1/FVC(%) which reflected airflow limitation and obstruction. PI-950 correlated closely with PFT results. Among the groups from stage 0-4, PI-950 reflected differences more sensitively than MLA and PI-910. Conclusion Quantitative MSCT study of lung attenuation can assess the changes of pulmonary parenchyma in patients with COPD by three-dimensional analysis. PI-950 is a rather sensitive index in quantitative study of pulmonary parenchymal changes in patients with COPD. |
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