| 刘学兵,王志刚,许川山,康娟,李攀,张勇,冉海涛.载竹红菌素脂质微泡的制备及对兔VX2肝肿瘤的显影实验[J].中国医学影像技术,2008,24(10):1508~1510 |
| 载竹红菌素脂质微泡的制备及对兔VX2肝肿瘤的显影实验 |
| Preparation of microbubbles containing hypocrellin and visualization to rabbit VX2 liver tumor |
| 投稿时间：2008-06-04 修订日期：2008-07-22 |
| DOI： |
| 中文关键词: 超声检查 微泡 竹红菌素 肿瘤 |
| 英文关键词:Ultrasonography Microbubble Hypocrellin Neoplasms |
| 基金项目:国家863计划(2006AA02Z4FO),国家自然科学基金重点项目(30430230),国家自然科学基金面上项目(30770565)。 |
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| 中文摘要: |
| 目的 制备一种载光动力药物的脂质超声微泡,测定物理特性,并观察其对兔VX2肝肿瘤的显影效果及过程。方法 采用机械振荡的方法制备载竹红菌素脂质微泡,并测定其粒径大小、分布、Zeta电位和包封率、稳定性及超声辐照后药物释放情况。采用不同超声模式观察微泡在兔VX2肝肿瘤的显像效果及过程。结果 载药微泡的粒径为(1052.4±322.7)nm,Zeta电位为+(21.1±7.4)mV,包封率为(88.1±4.6)％,超声辐照能够促使微泡释放药物,对兔VX2肝肿瘤的显影效果好。结论 载竹红菌素脂质微泡包封率高、微泡能够释放药物、显像好,符合理想的药物载体,为实时监控下的体内定位光动力治疗疾病提供了一种新的思路。 |
| 英文摘要: |
| Objective A kind of microbubbles containing hypocrellin were preparated and evaluated as a new ultrasound contrast agent for chemotherapeutic drug delivery. Methods The microbubbles containing hypocrellin (HA) were prepared by mechanical vibration. The resulting microbubbles containing hypocrellin were studied for size, Zeta potential, drug entrapment efficiency, drug release percentage. The enhancement of ultrasound imaging in vivo was assessed. Results The mean diameter of preparing microbubbles containing hypocrellin was (1052.4±322.7)nm. The Zeta potential was +(21.1±7.4)mV. The drug entrapment efficiency was (88.1±4.6)％. Different intensity ultrasound irradiated microbubbles containing hypocrellin, which ruptured microbubbles and released drugs. The imaging of the rabbit liver and tumor could be enhanced obviously. Conclusion The self-made lipid microbubbles containing HA are consistent to the standard of ideal drug vehicle. The microbubbles might be a useful tool for deliver chemotherapeutic drug, and thus providing a novel strategy for diagnose and photodynamic therapy of the tumor. |
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