| 孙美玉,王绍武,方敏,宋清伟.脊椎病变的MR弥散加权成像研究[J].中国医学影像技术,2008,24(10):1501~1504 |
| 脊椎病变的MR弥散加权成像研究 |
| Diffusion-weighted imaging of vertebral diseases |
| 投稿时间：2008-09-01 修订日期：2008-09-11 |
| DOI： |
| 中文关键词: 脊椎病变 弥散加权成像 磁共振成像 |
| 英文关键词:Vertebra Diffusion weighted imaging Magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 结合常规MRI,探讨磁共振弥散加权成像对脊椎良恶性病变的鉴别诊断价值。 方法 选择64例脊椎良恶性病变患者为研究对象,应用1.5T磁共振扫描仪采集数据,包括常规T1WI、T2WI和DWI,DWI b值分别选择70 s/mm2、100 s/mm2、165 s/mm2、300 s/mm2、500 s/mm2,经Functool 2 软件分析处理得到病变部位的表观弥散系数(ADC)值和指数弥散系数(EDC)值。采用统计软件包(SPSS 13.0)对以上观察内容进行统计学分析。 结果 DWI中,脊椎良、恶性病变的信号差异无显著性。b≤100 s/mm2时,弥散效应不明显;b>300 s/mm2时,图像信-噪比过低。当b=165 s/mm2时,其图像可满足诊断需要。当b=165 s/mm2时,脊椎良性病变的ADC值为(3.19±0.33)×10-4 mm2 /s,EDC值为(715.68±28.36)×10-3;脊椎恶性肿瘤(转移瘤)的ADC值为(1.87±0.12)×10-4 mm2 /s,EDC值为 (1466.25±41.69)×10-3。与恶性肿瘤相比,脊椎良性病变的ADC值明显偏高,EDC值明显偏低。 结论 脊椎良、恶性病变的DWI信号差异无显著性。因此,不能单纯根据DWI信号的高低对脊椎良、恶性病变进行鉴别诊断。脊椎EPI-DWI中,当b值在100~300 s/mm2时,能够得到适合临床诊断需要的图像。当b＝165 s/mm2时,脊椎ADC值和EDC值可作为良恶性病变鉴别诊断的指标之一。若ADC值大、EDC值小,则提示病变良性可能较大;反之则提示恶性肿瘤可能。 |
| 英文摘要: |
| Objective To evaluate the clinical application value of diffusion weighted imaging in differentiation of benign and malignant vertebral diseases. Methods Conventional MRI and DWI with b values as 70 s/mm2,100 s/mm2,165 s/mm2,300 s/mm2 and 500 s/mm2 respectively were performed in 64 patients with vertebral disease. ADC and EDC values were obtained on delineated ROI by the Functool 2 software system. The data were analyzed with soft-ware (SPSS, version 13.0). Results There was no significant difference of signal of DWI between benign and malignant vertebral diseases. The diffusion effects was not significant when b value was smaller than 100 s/mm2. The signal noise ratio was so low when b value was larger than 300 s/mm2. With b value as 165 s/mm2, the diffusion images were suitable for clinical diagnosis. When b value was 165 s/mm2, the ADCs of benign vertebral diseases were higher than those of malignant ones ( ×10-4 mm2 /s), and EDCs of benign group were lower than those of malignant ones ( ×10-3). Conclusion The signal of DWI is not reliable to distinguish benign from malignant vertebral diseases, however, ADCs and EDCs of diffusion weighted imaging are helpful for differentiation. |
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