| 程克斌,张晶,张薇,梁伟,李晓松,程晓光.表观扩散系数值在区分肌肉骨骼系统良、恶性肿瘤中的作用[J].中国医学影像技术,2008,24(10):1497~1500 |
| 表观扩散系数值在区分肌肉骨骼系统良、恶性肿瘤中的作用 |
| Value of apparent diffusion coefficient in MR diffusion-weighted imaging for differential diagnosis of benign and malignant musculoskeletal tumors |
| 投稿时间：2008-08-11 修订日期：2008-09-17 |
| DOI： |
| 中文关键词: 肌肉骼骨系统 肿瘤 扩散加权成像 表观扩散系数 磁共振成像 |
| 英文关键词:Musculoskeletal system Neoplasms Diffusion weighted imaging Apparent diffusion coefficient Magnetic resonance imaging |
| 基金项目:首都医学发展科研基金(2005-3033)。 |
| 作者 | 单位 | E-mail | | 程克斌 | 北京大学第四临床医学院,北京积水潭医院放射科,北京 100035 | | | 张晶 | 北京大学第四临床医学院,北京积水潭医院放射科,北京 100035 | | | 张薇 | 北京大学第四临床医学院,北京积水潭医院放射科,北京 100035 | | | 梁伟 | 北京大学第四临床医学院,北京积水潭医院放射科,北京 100035 | | | 李晓松 | 北京大学第四临床医学院,北京积水潭医院放射科,北京 100035 | | | 程晓光 | 北京大学第四临床医学院,北京积水潭医院放射科,北京 100035 | xiao65@263.net |
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| 中文摘要: |
| 目的 探讨ADC值在区分肌肉骨骼系统肿瘤良恶性中的作用。 方法 对33例患有肌肉骨骼系统肿瘤的患者进行MR常规T1加权,T2加权,压脂T2加权检查,以及3D Fast SPGR动态增强成像。MR扩散加权成像采用SS-EPI序列,b值分别取0、 700 s/mm2,在动态增强扫描图像上强化明显的区域作为扩散加权成像图上的感兴趣区,测定肿瘤的ADC值。 结果 在33例肿瘤中,良性肿瘤为17例,平均ADC值为(1.54±0.35)×10-3 mm2 /s,恶性肿瘤共有16例,平均ADC值为(1.45±0.45)×10-3 mm2 /s,二者之间无显著性差异(P>0.05)。 在33例病例中,共有6例软骨类肿瘤,平均ADC值(1.94±0.51)×10-3 mm2 /s;非软骨类肿瘤共有27例,平均ADC值(1.41±0.29)×10-3 mm2 /s,二者之间有显著差异(P<0.05)。除1例软骨类肿瘤外,所有软骨类肿瘤的ADC值均大于2.0×10-3 mm2 /s。结论 以MR动态增强图像来选取DWI图像上肿瘤的感兴趣区(ROI)而测得的ADC值不能区分肌肉骨骼系统肿瘤的良恶性;但是高ADC值(>2.0×10-3 mm2 /s)对诊断软骨类肿瘤有一定价值。 |
| 英文摘要: |
| Objective The purpose of this study was to determine whether the apparent diffusion coefficient (ADC) in diffusion-weighted imaging of MRI was useful for differential diagnosis of benign and malignant musculoskeletal tumors. Methods Thirty-three patients with musculoskeletal tumors underwent 1.5T conventional T1 weighted, T2 weighted, fat-suppressed T2 weighted, and dynamic-enhanced 3D Fast SPGR imaging to identify the lesions. Diffusion weighted images of the region of interest (ROI) were acquired by using a SS-EPI sequence with b values of 0 and 700 s/mm2. The ROIs on the diffusion-weighted images were selected as the maximal enhanced areas in the dynamic-enhanced images, and the ADC values were calculated. Results There were 17 benign tumors and 16 malignant tumors. The mean ADC values were (1.54±0.35)×10-3 mm2 /s and (1.45±0.45)×10-3 mm2 /s for benign tumors and malignant tumors, respectively. The difference was not significant (P>0.05). There were 6 cartilaginous tumors and 27 non-cartilaginous tumors. The mean ADC values were (1.94±0.51)×10-3 mm2/s for cartilaginous tumors and (1.41±0.29)×10-3 mm2/s for non-cartilaginous tumors, the difference was significant (P<0.05). Five patients with cartilaginous tumors had ADC values higher than 2.0×10-3 mm2/s. Conclusion The ADC values are not useful for differential diagnosis of benign and malignant musculoskeletal tumors. When the ADC value is higher than 2.0×10-3 mm2/s, there is an indication for cartilaginous tumors. |
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