| 宋英儒,黄仲奎.活体激发骨髓造血的磁共振波谱研究[J].中国医学影像技术,2008,24(8):1246~1250 |
| 活体激发骨髓造血的磁共振波谱研究 |
| Magnetic resonance spectroscopy of bone marrow mobilization in vivo |
| 投稿时间：2008-03-07 修订日期：2008-06-02 |
| DOI： |
| 中文关键词: 磁共振波谱 骨髓移植 CD34＋ |
| 英文关键词:Magnetic resonance spectroscopy Bone marrow transplantation CD34+ |
| 基金项目:国家留学基金(22845006)。 |
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| 摘要点击次数: 2090 |
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| 中文摘要: |
| 目的 用骨髓磁共振波谱(MRS)来监测被rhG-CSF激发后髂骨骨髓中水和脂肪的变化。 方法 选取将作自体干细胞移植的11名淋巴瘤和多发性骨髓瘤患者,注射rhG-CSF来激发骨髓干细胞释放前后,取髂骨内约8 mm边长的正立方体,用PRESS法进行单体素氢质子波谱分析。在rhG-CSF注射前(0周)和注射后1、2、4周等时间分别作MRS。采用1个固定的TE和11个不同的TR参数进行扫描,用于测定立方体内水和脂肪的T1值(T1w和T1f);计算水和脂肪波峰振幅比代表髂骨骨髓中水和脂肪的比值(water/fat),由公式W%= (water/fat)/(water/fat+1)和F%=1/(water/fat+1)可分别计算出骨髓中水和脂肪含量的百分比。对W%、T1w、F%、T1f等参数进行不同时间的纵向对比和同一时间不同参数的横向对比,并与外周血CD34＋的浓度等进行比较。 结果 W%、T1w、F%、T1f 在1、2、4周与0周相比,除了W%在1周与 0周对比的差异有显著性意义外,其余的差异均没有显著性意义。所有时间段的 W% 和T1w 之间的Pearson’s 相关关系没有显著性意义,而F%和T1f之间的Pearson’s 相关关系却有显著性意义,而且F% 和T1f之间的线性拟合也有显著性意义。 结论 骨髓干细胞被动员后第一周骨髓中相对水的含量明显增加。F%与T1f的相关关系密切,并其变化成线性相关,可作为MRS活体监测骨髓脂肪含量变化的量化指标。 |
| 英文摘要: |
| Objective To follow up the change of water and fat in iliac in magnetic resonance spectroscopy (MRS) after priming in rhG-CSF administration. Methods Eleven patients of lymphoma and myeloma during pretransplant priming were included in this study. MRS investigation was scheduled four times: at study entry, one- two- and four- weeks following priming. MRS were performed at post iliac of a cube 8 mm×8 mm×8 mm in 11 different sequences in order to calculated T1 of water component (T1w) and fat component (T1f). The peak amplitudes of the water and fat components (water/fat) were measured for the calculations: W%= (water/fat)/(water/fat+1), F%=1/(water/fat+1). Results W%, T1w, F% and T1f in 1 w, 2 w, 4 w were not significant difference comparing to that of 0 w except W% paired 0-1 w. Pearson’s correlation between W% and T1w was no significant, but F% and T1f, a linear fit of F% and T1f were significant. Conclusion The changed of water content was obvious in the first week after stem cells mobilization. The change of F% and T1f in bone marrow was parallel, and consequence to be indexes in following up the change of fat component in marrow. |
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