| 于明明 综述,王荣福 审校.靶向肿瘤血管多肽显像的研究进展[J].中国医学影像技术,2008,24(7):1125~1129 |
| 靶向肿瘤血管多肽显像的研究进展 |
| Progress of the targeted tumor vessel-binding peptide imaging |
| 投稿时间：2008-01-30 修订日期：2008-03-28 |
| DOI： |
| 中文关键词: 肽 肿瘤 血管 精氨酸-精氨酸-亮氨酸 |
| 英文关键词:Peptide Neoplasms Vessel Arg-Arg-Leu |
| 基金项目:国家自然科学基金(30470498,30670583)、国家重点基础研究发展计划(2006CB705705)、北京大学985II期基金(985-2-056)。 |
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| 中文摘要: |
| 肿瘤细胞如正常组织一样,存活需要氧气和代谢, 而血管生成对于肿瘤的生长是一个重要的过程。新生肿瘤血管与正常血管相比有独特的特点:新生肿瘤血管结构排列紊乱,扭曲并且扩张,它们在其内膜的表面表达特异性标记物,可以利用其表面的特异性标记物选择性靶向肿瘤血管。本文对近年来有关特异性靶向肿瘤血管的多肽显像,尤其对三肽序列精氨酸-精氨酸-亮氨酸(Arg-Arg-Leu, RRL)进行详细的介绍。 |
| 英文摘要: |
| Tumor cells, as normal tissues, need to receive oxygen and metabolites to survive, so angiogenesis is an essential process for the growth of solid tumors. The newly formed tumor vessels show characteristics which are different from the normal one. In fact, the vessels are structurally disorganized, tortuous and dilated and they express on their membrane surface peculiar markers, which can be used for the selective targeting of tumor blood vessels. In this paper, we reviewed the literature of peptide targeted to tumor vessels and their potential applications, especially introduced in detail for Arg-Arg-Leu. |
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