| 王慧芳,林琪,熊奕,刘涛,臧玲.11~14孕周胎儿颅脑横切面筛查主要颅脑畸形的临床价值[J].中国医学影像技术,2008,24(6):943~945 |
| 11~14孕周胎儿颅脑横切面筛查主要颅脑畸形的临床价值 |
| Clinical value of a cross-sectional view of the fetal brain in screening for major brain malformations during 11—14 weeks |
| 投稿时间：2008-01-28 修订日期：2008-03-25 |
| DOI： |
| 中文关键词: 颅脑畸形 早孕期筛查 超声检查 |
| 英文关键词:Brain malformations First trimester screening Ultrasonography |
| 基金项目:本课题受深圳市科技计划项目基金资助(200204036)。 |
| 作者 | 单位 | E-mail | | 王慧芳 | 暨南大学第二临床医学院,深圳市人民医院超声科,广东 深圳 518020 | kuangwhf2006@126.com | | 林琪 | 暨南大学第二临床医学院,深圳市人民医院超声科,广东 深圳 518020 | | | 熊奕 | 暨南大学第二临床医学院,深圳市人民医院超声科,广东 深圳 518020 | | | 刘涛 | 暨南大学第二临床医学院,深圳市人民医院超声科,广东 深圳 518020 | | | 臧玲 | 暨南大学第二临床医学院,深圳市人民医院超声科,广东 深圳 518020 | |
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| 中文摘要: |
| 目的 探讨11~14孕周胎儿颅脑横切面筛查主要颅脑畸形的临床价值,提高检查的诊断率。 方法 2004年1月－2007年6月共4985例孕妇进行11~14孕周超声检查,测量胎儿颈项透明层厚度和观察胎儿主要形态结构,重点观察胎儿颅脑横切面。 结果 11~14孕周超声共诊断14例主要颅脑畸形,颅盖缺失9例,全前脑2例,脑膨出3例,均引产证实;漏诊7例主要颅脑畸形,颅盖缺失3例,全前脑2例,脑膨出2例,于中孕期超声系统筛查诊断并引产证实。 结论 超声能在11~14孕周筛查主要颅脑畸形。胎儿颅脑横切面观察卵圆形的颅骨光环、脑中线、侧脑室及蝴蝶形的脉络膜是诊断的关键。规范的培训将增加胎儿颅脑畸形的检出率。 |
| 英文摘要: |
| Objective To review the clinical value of a cross-sectional view of the fetal brain between 11－14 weeks' ultrasound scan, so as to avoid potential diagnostic pitfalls. Methods A total of 4985 pregnancies underwent 11－14 weeks' ultrasound scan. Measured the thickness of nuchal translucengcy (NT) and evaluated fetal major anatomy structure, specially a cross-sectional view of the fetal brain. Results There were 14 major brain malformations detected at 11－14 weeks and confirmed by postmortem examination, including 9 cases of acranium, 2 cases of holoprosencephaly and 3 cases of encephalocele. There were 7 major brain malformations missed at 11－14 weeks and detected at the second trimester and confirmed by postmortem examination, including 3 cases of acranium, 2 cases of holoprosencephaly and 2 cases of encephalocele. Conclusion Detection of major brain malformations is feasible during the 11－14 weeks' scan. A cross-sectional view of the fetal brain is the key to detect major brain malformations during 11－14 weeks, including ovum-shaped skull, the presence of a midline, the lateral ventricles and a "butterfly" choroids plexuses. Proper criterion training should increase the detection rate of brain malformations. |
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