| 赵季红,姜铁民,李玉明,陈少伯,梁国庆,刘军翔,罗涛.血管内超声-虚拟组织学对易损斑块的临床研究[J].中国医学影像技术,2008,24(6):885~887 |
| 血管内超声-虚拟组织学对易损斑块的临床研究 |
| Clinical study of vulnerable atherosclerotic plaques detection by using intravascular ultrasound-virtual histology |
| 投稿时间：2008-01-07 修订日期：2008-04-17 |
| DOI： |
| 中文关键词: 血管内超声-虚拟组织学 急性冠脉综合征 心绞痛 易损斑块 |
| 英文关键词:Intravascular ultrasound-virtual histology Acute coronary syndrome Angina Vulnerable plaques |
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| 中文摘要: |
| 目的 通过血管内超声-虚拟组织学( IVUS-VH)技术对急性冠脉综合征(ACS)和稳定型心绞痛(SA)患者冠状动脉粥样斑块进行实时分析,探讨易损斑块的性质及其临床相关性。方法 对16名ACS患者冠脉进行IVUS-VH研究,与15名SA 患者比较,分析两者斑块的性质及其与临床血脂水平的相关性。结果 ACS患者易损斑块发生率显著高于SA患者(P＜0.05),斑块组成以纤维脂肪组织和坏死成分为主,而SA患者斑块纤维成分和钙化成分较高。两组中纤维脂肪组织与低密度脂蛋白(LDL)呈正相关(r=0.08, P＜0.05),与高密度脂蛋白(HDL)呈负相关(r=-0.06, P＜0.05)。结论 通过IVUS-VH发现,ACS患者易损斑块发生率明显高于SA患者,且斑块成分不同,与临床血脂水平具有相关性。 |
| 英文摘要: |
| Objective To compare the tissue characteristics of the atherosclerotic plaques in acute coronary syndrome (ACS) and stable angina (SA) patients by intravascular ultrasound-virtual histology (IVUS-VH) and assess their clinical correlates with plasma lipoprotein. Methods In 16 ACS patients and 15 SA patients, culprit lesions were detected with IVUS-VH to investigate the characteristics of the atherosclerotic plaque and its clinical relevance. Results ACS patients presented a significantly higher prevalence of vulnerable plaques than SA patients (P＜0.05). A clear clustering pattern, consisted mainly of fibro-fatty tissue and necrotic core-rich tissue, was seen along the ACS coronaries. There were higher levels of fibrous tissue and dense cacium tissue in SA patients compared with ACS patients. In these two groups, fabro-fatty tissue correlates positively with the plasmic LDL levels (r=0.08, P＜0.05), and negatively with the plasmic HDL levels (r=-0.06, P＜0.05). Conclusion As shown by IVUS-VH, the prevalence of vulnerable plaque in ACS patients was much higher than in SA patients, coupled with different intra-plaque composition, which was associated with serum lipid level. |
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