| 李焕斌,张雄,王玲,张琦.帕金森病99mTc-TRODAT-1多巴胺转运蛋白显像及与UPDRS评分相关性研究[J].中国医学影像技术,2008,24(5):773~776 |
| 帕金森病99mTc-TRODAT-1多巴胺转运蛋白显像及与UPDRS评分相关性研究 |
| Dopamine transporter imaging study of patients with Parkinson's disease and the correlation with different UPDRS score |
| 投稿时间：2008-01-15 修订日期：2008-02-07 |
| DOI： |
| 中文关键词: 帕金森病 UPDRS 99mTc-TRODAT-1 体层摄影术,发射型计算机,单光子 |
| 英文关键词:Parkinson's disease UPDRS 99mTc-TRODAT-1 Tomography, emission-computed, single-photon |
| 基金项目:本课题受温州市科技局资助项目(Y2005A020)资助。 |
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| 中文摘要: |
| 目的 研究99mTc-TRODAT-1多巴胺转运蛋白SPECT显像与PD UPDRS评分相关性,以探讨其在帕金森病(PD)病情与病程监测中的价值。 方法 24例临床确诊PD患者和10例对照者,进行99mTc-TRODAT-1多巴胺转运蛋白显像,计算纹状体与小脑、尾状核与小脑及壳核与小脑放射性计数比值;应用UPDRS对患者的运动功能进行评分,将UPDRSⅡ、Ⅲ、Ⅴ和Ⅵ的评分分别与起病肢体对侧、同侧及双侧纹状体/小脑放射性计数进行相关性分析。根据Hoehn-Yhar分级,将24例PD患者分为早期、中期和晚期,分析不同病程纹状体放射性比值。 结果 PD患者纹状体摄取99mTc-TRODAT-1随病情严重程度增加而逐渐减少,与UPDRSⅡ、Ⅲ、Ⅴ和Ⅵ评分之间存在负相关(r=-0.608, -0.671, -0.661, -0.639,P均<0.05);PD病程越晚,CN/CB 及 PT/CB 放射性摄取比值越低。 结论 99mTc-TRODAT-1 SPECT转运蛋白显像可用于PD的早期诊断及病程分期,纹状体/小脑放射性计数比值作为PD诊断及监测病情轻重的半定量分析指标,与UPDRS评分具有相关性,在一定程度上可作为病情进展情况的预判和客观随访指标。 |
| 英文摘要: |
| Objective To evaluate the patient's condition and course of desease by studying the relationship of 99mTc-TRODAT-1 SPECT imanging with UPDRS score . Methods Twenty-four PD patients and 10 controls received 99mTc-TRODAT-1 dopamine transporter imaging. The region of interest of strialiam, as well as CN and PT, were drawn by two experienced nuclear medicine specialist. Semiquantiative analysis methods were used to calculate the radioactive uptake ratio, and the DAT differeances of all ROIs were compared. We also used United Parkinson Disease rating scale to assess movement function of PD patients. Then the relationship between the subscales of UPDRS Ⅱ, Ⅲ, Ⅴ, Ⅵ and striatum/cerebellum were analysed. Results For group of PD: the ST/CB, as well as CN/CB and PT/CB all decreased. As disease develops, the uptake of 99mTc-TRODAT-1 in striatum decreased gradually. There was a negative correlation between ST/CB ratios and UPDRS scores(r=-0.608, -0.671, -0.661, -0.639, P<0.05). Conclusion 99mTc-TRODAT-1 DAT SPECT showed the value not only in the diagnose of early stage PD, but also in the evaluation of disease course. ST/CB radio ligand binding ratios can be used as a kind of semiquantiative index when diagnosing and evaluating severity of PD.It is helpful to monitor PD progress and correlated to the UPDRS scores to some extent. |
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