| 秦朝军,黄盛才,王仁生,颜李梅,韦小林,马加强.鼻咽癌原发灶18F-FDG和11C-胆碱显像的代谢特征[J].中国医学影像技术,2008,24(5):769~772 |
| 鼻咽癌原发灶18F-FDG和11C-胆碱显像的代谢特征 |
| The metabolize character of 18F- |
| 投稿时间：2007-12-26 修订日期：2008-03-11 |
| DOI： |
| 中文关键词: 鼻咽肿瘤 标准摄取值 18F 氟脱氧葡萄糖 |
| 英文关键词:Nasopharyngeal neoplasms Standardized uptake value Fluorodeoxyglucose F18 |
| 基金项目:本课题受广西自然科学基金(桂科自0640124)资助。 |
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| 中文摘要: |
| 目的 探讨鼻咽癌原发灶18F-FDG和11C-胆碱显像的代谢特征。方法 对35例病理确诊为原发鼻咽癌的病例行鼻咽部18F-FDG PET/CT 30 min和60 min显像,其中的20例在随后1~3天内行鼻咽部11C-胆碱显像。分别测量不同显像条件下肿瘤原发灶(T)和非肿瘤区域(NT)的SUVmax,并计算和比较其T/NT比值。结果 18F-FDG PET/CT显像:30 min、60 min T/NT比值的中位数分别为3.20与4.05,95%百分位数(单侧)分别为1.83和2.63;30 min、60 min T/NT比值( Ax-G ±s)分别是3.78±1.49和5.56±3.72,后者明显高于前者(P<0.05,t’=2.2649),增高幅度为47.09%。11C-胆碱显像:T/NT的中位数是3.76, 95%百分位数(单侧)是2.00,T/NT是4.13±1.71。结论 鼻咽癌原发灶对18F-FDG和11C-胆碱显像均高度敏感。 |
| 英文摘要: |
| Objective To study the metabolic character of 18F-FDG and 11C-choline PET/CT image in the patients with primary nasopharyngeal carcinoma. Methods Thirty-five cases of primary nasopharyngeal carcinoma diagnosis by pathology, were imaged separately by 18F-FDG PET/CT in the period of 30 min and 60 min after 18F-FDG injection. Of 20 cases add an extra 11C-choline PET/CT imaging in 1-3 days after 18F-FDG PET/CT imaging. And then measured and compared theirs T/NT(target SUVmax/non target SUVmax) ratios in the imaging. Results The median of T/NT in 18F-FDG PET/CT imaging in the period of 30 min and 60 min were 3.20 and 4.05 respectively, and the percentile of 95% was 1.83 and 2.63 separately. The averages and standard deviation of T/NT in 30 min and 60 min imaging were 3.78±1.49 and 5.56±3.72; the latter was obvious higher than the former (P<0.05,t’=2.2649) which increesed 47.09%. The median of T/NT in 11C-choline PET/CT imaging was 3.76, and the percentile of 95% was 2.00. The average and standard deviation of T/NT in 11C-choline imaging was 4.13±1.71. Conclusion Primary focus of nasopharyngeal carcinoma was hypersensitive to 18F-FDG and 11C-choline. |
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