| 陈方满,焦旭东,汪和平,汪国祥,黄新宇.原发性肺癌DSA表现与血清VEGF表达的相关性研究[J].中国医学影像技术,2008,24(3):430~433 |
| 原发性肺癌DSA表现与血清VEGF表达的相关性研究 |
| Correlation between the appearances of DSA and serum VEGF expression of lung cancer |
| 投稿时间：2007-10-26 修订日期：2008-12-24 |
| DOI： |
| 中文关键词: 肺癌 VEGF 数字减影血管造影 相关性 |
| 英文关键词:Lung neoplasms VEGF Digital subtraction angiography Correlation |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨肺癌患者支气管动脉DSA造影征象、血清血管内皮生长因子(VEGF)表达水平的关系;研究两者之间的相关性。 方法 应用酶联免疫吸附法(ELISA)定量检测40例肺癌(鳞癌20例,腺癌17例,末分化癌3例)患者及40例健康体检者血清中的VEGF; 40例肺癌患者行肿瘤血管DSA检查并进行分析、评估。 结果 ①肺癌组血清VEGF水平明显高于正常组(P＜0.01);各病理分型之间无显著差别(P＞0.05);临床分期不同VEGF含量不同(P＜0.05);肿瘤内部有无坏死有明显差异(P＜0.05);②DSA造影示供血动脉增粗,肿瘤血管呈网格状,瘤体染色为富血供者21例,中等血供者12例,少血供者7例;9例显示B-P分流征;38例示窃血征;纵隔淋巴结染色20例。 结论 肺癌血供与血清VEGF表达呈正相关,评价肿瘤血管不仅能指导临床治疗,而且能客观评估患者的现状与预后。 |
| 英文摘要: |
| Objective To study the correlation between the DSA manifestations and expression of serum VEGF index of pathology in patients with lung cancer. Methods 40 lung cancer serum specimens were detected by sandwich enzyme-linken immunoabsorbent assay (ELISA) and 40 normal healthy as controls; 40 lung cancer DSA appearances were analyzed and evaluated. Results ①Serum VEGF level of patients with lung cancer was significantly higher than that in control group (P＜0.01); there was no significant correlation in various pathologic type (P＞0.05); the serum VEGF level was significantly higher in advanced lung cancer patients than that in early stage (P＜0.05); ②DSA demonstrated that the supply arteries were enlarged, tumorous vessels were also seen; obvious tumor stain occurred in 21 cases, middling stain in 12 cases and less stain in 7 cases; B-P shunt was in 9 cases, lymphnode stain in 20 cases. Conclusion There was positive correlation between degree of blood supply and the serum level of VEGF. Estimate the tumor vessel can not only instruct the interventional therapy but also objectively evaluate the status quo and prognosis of patients. |
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