| 姜蕾,杜湘珂,周诚,陈敏,周意明,纪立伟,孙非,申皓.利用1H MRS进行在体乳腺癌中复合胆碱外参照法定量的研究[J].中国医学影像技术,2008,24(3):393~397 |
| 利用1H MRS进行在体乳腺癌中复合胆碱外参照法定量的研究 |
| Quantification of total choline compound in in-vivo breast cancer with external standard with 1H magnetic resonance spectrum |
| 投稿时间：2007-10-09 修订日期：2007-11-09 |
| DOI： |
| 中文关键词: 磁共振氢质子波谱 乳腺肿瘤 胆碱 定量 |
| 英文关键词:Proton magnetic resonance spectroscopy (1H MRS) Breast neoplasms Choline Quantification |
| 基金项目: |
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| 摘要点击次数: 2484 |
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| 中文摘要: |
| 目的 探讨如何用外参照法利用氢质子磁共振波谱(1H MRS)对在体乳腺癌中的复合胆碱进行绝对定量。方法 配制5个不同浓度的胆碱测试模型及一个胆碱校对模型。在基本相同的条件下,对各测试模型的同一位置进行MRS采集,统计胆碱峰峰下面积与胆碱浓度之间是否呈线性相关。对水模进行T1WI成像,绘制不同位置信号强度的变化曲线。对同一校对模型的同一位置采用不同大小的体素进行MRS采集,统计体素大小与胆碱峰峰下面积是否呈线性相关。测量胆碱测试模型及校对模型中胆碱的T1及T2值。验证胆碱浓度绝对定量的校对公式。对7例乳腺癌病人进行乳腺MRS采集,利用校对公式以胆碱校对模型中的胆碱浓度为参照计算出乳腺癌中复合胆碱的浓度。结果 胆碱测试模型的胆碱峰峰下面积与胆碱浓度之间呈线性相关。同一模型同一位置胆碱峰峰下面积与体素大小呈线性相关。测试模型及校对模型中胆碱的T1及T2值分别为1902.5/1032.8、2426.3/989.4。利用校对公式估计出的校对模型的胆碱浓度为(5.2±1.0)mM,与校对模型的实际浓度比较二者无显著差异(t＝0.6,P>0.05)。7例乳腺癌中的复合胆碱浓度为(3.64±2.52)mM。结论 外参照法是进行乳腺癌中复合胆碱浓度定量的可行及可靠的方法。 |
| 英文摘要: |
| Objective The aim was to quantify the total choline compound (tCho) in in-vivo breast cancer with external standard with 1H magnetic resonance spectrum (MRS). Methods Five bottles of choline and CuSO4 solution with different choline concentration were made as test models and 1 bottle of choline solution as calibration model. Under almost the same conditions, MRS acquisition was performed on the same position on different test models and linear correlation between areas under choline peaks and choline concentrations was analyzed. MRS acquisition with different sizes of voxels on the same position on the same model was performed and linear correlation between voxel sizes and areas under choline peaks was analyzed. The uniformity of signal intensity over the volume enclosed within the coil was tested by performing T1WI on water model. T1 and T2 values of choline in test model and calibration model were measured, respectively. Then the calibration strategy of quantification was tested. At last, we performed MRS acquisition on 7 breast cancers and calculated their choline concentrations using calibration equation taking calibration phantom as the external standard. Results Linear correlation existed between subpeak areas of choline and choline concentration as well as between voxel sizes and subpeak areas. T1 and T2 values of test model and calibration model were 1902.5/1032.8, 2426.3/989.4, respectively. With the calibration strategy, the absolute concentration of choline in the calibration phantom was (5.2±1.0)mM,which had no significant difference with the actual concentration. The average concentration of 7 breast cancers were (3.64±2.52)mM. Conclusion Quantification of in-vivo choline with 1H magnetic resonance spectrum with external standard is an applicable and reliable method. |
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