| 牟宗霞,侯文生,郑小林,吴小鹰,沈珊,AnnetteMSterr,彭承琳.基于fMRI的力量调节速度相关神经兴奋模式的初步研究[J].中国医学影像技术,2008,24(3):341~345 |
| 基于fMRI的力量调节速度相关神经兴奋模式的初步研究 |
| An fMRI based pilot study on the nerve excitabilityfor force-regulating speed |
| 投稿时间：2007-10-19 修订日期：2007-12-19 |
| DOI： |
| 中文关键词: 握力运动 磁共振成像 速度 脑运动区 小脑 |
| 英文关键词:Grasp Magnetic resonance imaging Rate Brain motor cortex Cerebellum |
| 基金项目:国家自然科学基金(30770546),重庆市自然科学基金(2006BB2043),重庆市自然科学基金(2007BB5148)。 |
| 作者 | 单位 | E-mail | | 牟宗霞 | 重庆大学生物医学工程系,重庆 400044 | | | 侯文生 | 重庆大学生物医学工程系,重庆 400044 | hws21cn@yahoo.com.cn | | 郑小林 | 重庆大学生物医学工程系,重庆 400044 | | | 吴小鹰 | 重庆大学生物医学工程系,重庆 400044 | | | 沈珊 | Department of Psychology, University of Surrey, Guildford, Surrey, Gu2 7XH, UK | | | AnnetteMSterr | Department of Psychology, University of Surrey, Guildford, Surrey, Gu2 7XH, UK | | | 彭承琳 | 重庆大学生物医学工程系,重庆 400044 | |
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| 中文摘要: |
| 目的 研究视觉引导的握力运动力量调节速度快慢所激活脑功能区的异同。 方法 15例正常受试者右手进行四种模式(由视觉反馈增益和力量变化速度两个因素组合而成)握力运动,同时进行BOLD fMRI扫描,比较四种模式脑激活的异同。 结果 四种模式握力运动均可激活初级躯体感觉运动区(SMC),双侧前运动区(PMC)、辅助运动区(SMA)、小脑、基底节(BG),对侧后顶叶(PPC),Brodmann 40等。其中,随着力量调节速度的提高,SMC激活强度、范围都提高,而BG恰好相反,SMA激活强度提高但范围缩小,小脑表现不明显。 结论 SMC对力量输出的快速调节作用明显;PPC,PMC参与了将视觉信息转化成力量输出这一过程;BG在快速运动时受到SMC、SMA的制约。 |
| 英文摘要: |
| Objective To study the brain functional activations under different power adjusting speed of grasping task. Methods A group of healthy volunteers (n=15) were recruited to participate in the grasping task using right hand, and there were four different grasping paradigms made up of two kind of both visual feedback range and force-regulating rate. The activated areas were evaluated by BOLD fMRI, and functional responses were established by student’s group t test analysis. Results All four different grasping tasks could activate the primary somatosensory cortex (SMC), bilateral pre-motor area (PMC), supplementary motor area (SMA), cerebellum, basal ganglia (BG), the contralateral posterior parietal cortex (PPC), Brodmann 40, et al. Significant frequency-dependent blood oxygen level dependent signal increases were demonstrated in ipsilaterally or contralaterally SMC in both the size and the intensity, while the situation of BG was opposed. The intensity of the active area in SMA was swelled while the extent of it was decreased. There was no significant difference in the cerebellum. Conclusion The SMC plays a major role in regulating the power of the hand grasp with different rate. PPC and PMC are hypothesized to attend the process of transferring the visual information to motor output, namely visuomotor transformations. The reversed BG rate/response function, as compared with SMC and SMA, might reflect the inhibitory action of frontal motor areas on it. |
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