| 于彤,朱家瑞,许根祥.病灶靶/本底比值随时间的变化规律观察[J].中国医学影像技术,2008,24(1):134~136 |
| 病灶靶/本底比值随时间的变化规律观察 |
Variation of lesion/background ratios with time in
malignant and benign tumor |
| 投稿时间：2007-07-04 修订日期：2007-11-21 |
| DOI： |
| 中文关键词: 符合线路(SPECT／CT) 脱氧葡萄糖 双时相显像 靶/本底比值 |
| 英文关键词:SPECT／CT Deoxyglucose Dualtime point imaging Lesion/Background ratios |
| 基金项目: |
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| 摘要点击次数: 1876 |
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| 中文摘要: |
| 目的 回顾性分析符合线路 (SPECT／CT)显像,观察良性病灶和恶性病灶18F-FDG摄取随时间的变化规律,指导合理选择FDG显像时段。方法 对160人次的(男112人次,女48人次)的262个病灶(恶性176个,良性86个)FDG肿瘤显像的图像进行回顾性分析。病人无糖尿病病史,空腹血糖正常,禁食6小时以上,静脉注射18F-FDG 5.0~10.32 mCi (185~381.84 MBq),平均为(7.5±1.40) mCi (227.5 MBq)后使用多功能ECT MillenniunTMVG8+Hawkeye (SPECT/CT)进行2D图像采集。最早显像时间为66 min,最晚为399 min(其中有一部分选择的是延时显像数据)。每人采集1~3个床位,每床位40 cm。用CT数据进行衰减校正,使用OSEM法进行图像重建。结果 分析病灶靶/本底比值时间曲线:①注药后的120~180 min,良恶性病灶的靶/本底比值差别最显著。此时为鉴别良恶性病灶的最佳显像时间。②双时相采集可以根据实际情况选择:①注药后30 min时进行第一时相图像采集,90 min进行第二时相的图像采集。此时,良性病灶的靶/本底比值降低,恶性病灶为初始上升期。有利于良性病灶的排除。②第一时相注药后的60~120 min内进行,第2时相在注药后的120~180 min内进行,有利于鉴别恶性病灶(此时良性病灶为平台期、缓慢上升或下降期),恶性病灶为上升期。3 必要时可进行3时相显像,通过三个时间点病灶摄取值的特点,鉴别病灶的性质。理论上会提高FDG的鉴别诊断价值。结论 准确掌握不同性质病灶的FDG代谢时间曲线,利用多时相显像技术可以更好利用和提高FDG肿瘤显像的价值。 |
| 英文摘要: |
| Objective To understand the Lesion/Background Ratio(L/B) varying with time in malignant and benign tissues the SPECT／CT images were analyzed retrospectively. It will benefit us to acquire whole body scan at appropriate time point. Methods The study population consisted of 160 patients(male: 112, female: 48)with 262 lesions(malignant: 176,benign:86).The patients were administrated 5.0-10.32 mCi (185-381.84 MBq) 18F-FDG by intravenous injection. Images were acquired (2-3 beds) with multifunction ECT MillenniunTMVG8+Hawkeye (SPECT/CT) afte injection in 2D mode, reconstructed using the method of OSEM (21 subsets, twice iterations). The final diagnoses of these patients were proven either by histopathology or by biopsy,or by a clinical and radiographic follow-up.The statistical analysis of quantitatie data were performed by SPSS 13.0. Results The L/B ratio of benign tissues falled down to its lowest point at 120－180 min after injection, and achieved its peak again at 180－240 min (the first peak was estimated at about 30 min after injection). While, malignant tumor showed a greater rise of L/B until it achieved the peak at 240－300 min after injection. Synthesising and analysising the trend lines which we got in this study and some predecessor’s findings, we have a conclusion that, besides the well known method(i.e. the first phase image aquired at 60-120 min and delayed phase image at 120-180 min after injection)which show us the L/B ratio rising of malignant lesions, dualtime point 18F-FDG imaging can also be aquired at 30 min and 90 min, alternativly. And what different it from the above is that it show us the falling down of L/B ratio of the benign tusses. IF necessary, we can use three time point imaging to improve the diagnosis accuracy.The trend line also show that it is at 120-180 min after injection when L/B ratio achieves its stronger contrast. Conclusion Understanding the metabolism rule of the malignant lesions and benign lesions well benefit us to select the optimal scan time or multi-phase techniques in order to improve the diagnosis value of FDG SPECT/CT tumor imagings. |
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