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张瑞平,李健丁,姜增誉,乔英,鄂林宁.大肠癌腹腔内转移SCT征象与MVD、nm23表达的关系[J].中国医学影像技术,2008,24(1):107~110

大肠癌腹腔内转移SCT征象与MVD、nm23表达的关系

Correlation between spiral CT features of metastasis in abdominal cavity and expression of MVD and nm23 in colorectal carcinoma

投稿时间：2007-03-14 修订日期：2007-05-14

DOI：

中文关键词: 大肠癌血管形成微血管密度转移抑制基因体层摄影术,X线计算机

英文关键词:Colorectal cancer Angiogenesis Microvessel density nm23 Tomography, X-ray computed

基金项目:

作者	单位	E-mail
张瑞平	山西医科大学第一医院放射科,山西太原 030001	zrp_7142@eyou.com
李健丁	山西医科大学第一医院放射科,山西太原 030001	cjr.lijianding@vip.163.com
姜增誉	山西医科大学第一医院放射科,山西太原 030001
乔英	山西医科大学第一医院放射科,山西太原 030001
鄂林宁	山西医科大学第一医院放射科,山西太原 030001

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中文摘要:

目的探讨大肠癌腹腔内转移螺旋CT征象与MVD、nm23表达的关系。方法 40例大肠癌患者,行螺旋CT扫描,并用免疫组化SP法,检测MVD和nm23表达。结果 SCT判断大肠癌腹腔内淋巴结转移准确率为77.5%,腹膜转移准确率为90%,肝、肾上腺、卵巢的转移准确率为100%。大肠癌腹腔内转移与无转移组间的CT强化程度、MVD和nm23表达的比较,差异具有统计学意义(P<0.05)。SCT强化程度与MVD之间正相关(r=0.963, P<0.001),两者均与nm23的表达负相关(r₁=-0.971, P <0.001; r₂=-0.958,P <0.001)。结论 SCT扫描可准确反映大肠癌腹腔内转移情况。nm23的失活可能是大肠癌转移的因素,肿瘤血管生成可能是大肠癌转移的促进因素。CT强化程度可作为一定量指标初步判断肿瘤血管生成,来帮助我们对大肠癌的转移进行推断。

英文摘要:

Objective To investigate the correlation between spiral CT features of metastasis in abdominal cavity and expressions of nm23 and MVD in colorectal carcinoma. Methods Forty patients with colorectal carcinoma were examined by SCT before the operation. Expressions of nm23 and MVD in 40 patients with colorectal carcinoma diagnosed by pathology were examined immunohistochemically using SP techniques. Results The accuracy of SCT features for lymph node metastasis in abdominal cavity was 77.5%. The accuracy of peritoneum metastasis in colorectal carcinoma was 90.0% and the accuracy of liver, adrenal gland, ovaries of metastasis by SCT was 100%. CT enhancement and expressions of nm23 and MVD between metastasis and no metastasis in abdominal cavity were statistically significant in each of groups (P<0.05). The CT extent of enhancement positively correlated with MVD (r=0.963, P<0.001). The CT extent of enhancement and MVD negatively correlated with nm23 (r₁=-0.971, P<0.001; r₂=-0.958, P<0.001). Conclusion SCT scan for the metastasis of abdominal cavity were reliable techniques in colorectal carcinoma.The inactivation of nm23 may be a factor in the metastasis of colorectal carcinoma. And tumor angiogenesis may be a stimulative factor in the metastasis of colorectal carcinoma. CT extent of enhancement might be a quantitative index for tumor angiogenesis. And it may help us to predict the metastasis of colorectal carcinoma.

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