| 路晶,周翔,谢明星,王新房,吕清.超声造影剂灌注曲线斜率与流速相关性的初步研究[J].中国医学影像技术,2007,23(11):1717~1720 |
| 超声造影剂灌注曲线斜率与流速相关性的初步研究 |
| Correlation between slope rate of flash-replenishment curve of ultrasonic contrast imaging and the flow velocity in the model of microcirculatory dynamics: initial exploration |
| 投稿时间：2007-06-06 修订日期：2007-09-04 |
| DOI： |
| 中文关键词: 超声造影剂 连续灌注 Flash-replenishment |
| 英文关键词:Ultrasound-contrast agent Constant perfusion Flash-replenishment |
| 基金项目: |
| 作者 | 单位 | E-mail | | 路晶 | 华中科技大学同济医学院附属协和医院超声影像科,湖北省分子影像重点实验室,湖北 武汉 430022 | | | 周翔 | 华中科技大学同济医学院附属协和医院超声影像科,湖北省分子影像重点实验室,湖北 武汉 430022 | | | 谢明星 | 华中科技大学同济医学院附属协和医院超声影像科,湖北省分子影像重点实验室,湖北 武汉 430022 | xiemx64@126.com | | 王新房 | 华中科技大学同济医学院附属协和医院超声影像科,湖北省分子影像重点实验室,湖北 武汉 430022 | | | 吕清 | 华中科技大学同济医学院附属协和医院超声影像科,湖北省分子影像重点实验室,湖北 武汉 430022 | |
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| 中文摘要: |
| 目的 探讨超声Flash-replenishment成像技术中超声造影剂灌注曲线斜率与流速的相关性。方法 采用自制动力泵-超滤纤维系统模拟器官微循环血流动力学,建立微循环血流模型。连续输注20 ml造影剂SonoVue(1∶3稀释),应用FR成像技术,分别测定微循环流速为0.25 mm/s、0.5 mm/s、1 mm/s、2 mm/s、4 mm/s、8 mm/s时造影剂的再灌注曲线斜率β,对β值与实际流速进行相关性分析。结果 微循环流速为2~8 mm/s时β值与实际流速相关性良好,r=0.97;微循环流速为0.25~1 mm/s,二者相关性较差,r=0.44。结论 微循环流速低于1 mm/s以下时,造影剂再灌注曲线的β值与实际流速相关性差,故低流速状态下造影剂的灌注定量方法有待进一步研究。 |
| 英文摘要: |
| Objective To investigate the correlation between the slope of flash-replenishment curve of ultrasonic contrast imaging and the flow velocity in the model of microcirculatory dynamics. Methods An in-vitro model of microcirculatory dynamics was built up using pump-ultrafiltration fiber system made by ourselves. The values of β (the slope rate of time-intensity curve of contrast) derived from the flash-replenishment imaging technique were measured at the flow velocity of 0.25 mm/s, 0.5 mm/s, 1 mm/s, 2 mm/s, 4 mm/s, 8 mm/s, respectively. The correlation between the values of β and the different flow velocities was analyzed. Results The value of β and flow velocity correlated well within the range of 2 mm/s－8 mm/s (r=0.97). On the other hand, the correlation of β and flow velocity from 0.25 mm/s to 1 mm/s was poor (r=0.44). Conclusion It is a complex problem that the correlation between the value of β and microcirculation flow velocity is poor when the velocity is slower than 1 mm/s. The perfusion quantification for the very low flow velocity demands further research. |
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