| 江素芳,彭旭兰,梁宏伟,刘炯,高桂珠.不同腺苷输注时间的负荷99Tc-MIBI心肌灌注显像对冠心病心肌缺血评价的比较[J].中国医学影像技术,2007,23(11):1706~1708 |
| 不同腺苷输注时间的负荷99Tc-MIBI心肌灌注显像对冠心病心肌缺血评价的比较 |
| Comparison of different adenosine infusion time by use of 99Tcm-MIBI myocardial perfusion imaging for coronary artery disease |
| 投稿时间：2007-05-16 修订日期：2007-08-30 |
| DOI： |
| 中文关键词: 冠状动脉疾病 腺苷 放射性核素显像 |
| 英文关键词:Coronary disease Adenosine Radionuclide imaging |
| 基金项目: |
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| 摘要点击次数: 3088 |
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| 中文摘要: |
| 目的 评价4 min腺苷负荷试验心肌灌注显像对冠心病心肌缺血的临床应用价值,并与传统6 min负荷试验进行了对比研究。方法 将研究对象按性别、年龄、冠心病的严重程度(依据冠状动脉造影结果)及合并症等进行配对,分为4 min腺苷负荷组(4 min组)和6 min腺苷负荷组(6 min组),每组32例。两组病例均经肘静脉用注射泵持续注入腺苷,剂量为0.14 mg·kg-1·min-1,用药时间为4 min和6 min,于注射腺苷3 min末,分别从肘静脉注入99Tcm-MIBI 740 MBq。腺苷负荷心肌灌注显像在注射显像剂后1.5 h进行,隔日进行静息心肌灌注显像。结果 ①4 min组和6 min组腺苷负荷心肌显像对冠心病心肌缺血的敏感性、特异性、准确率分别为89%、80%、88%和92%、83%、91%,两组比较P均>0.05。②4 min组和6 min组不良反应总的发生率分别为78%和88%,两率及组间各不良反应发生率比较差异无显著性。结论 4 min腺苷负荷心肌灌注显像对冠心病心肌缺血有较高的诊断价值,可达到6 min腺苷负荷试验的诊断效能;且因用药时间短,患者易耐受。 |
| 英文摘要: |
| Objective To assess the clinical value of four-minute adenosine infusion 99Tcm-MIBI myocardial perfusion imaging for coronary artery disease (CAD), in comparison with six-minute infusion. Methods The patients were matched and divided into four-minute adenosine infusion and six-minute adenosine infusion, each protocol had 32 patients. In two groups, adenosine was infused at a rate of 0.14 mg·kg-1·min-1 intravenously for four minutes and six minutes. At the end of three minute of adenosine infusion, 740 MBq 99Tcm-MIBI was injected intravenously. SPECT myocardial imaging acquisition was obtained 1.5 hours after adenosine infusion, rest myocardial perfusion imaging would be performed following day. Results ①In four-minute and six-minute protocols, the sensitivity, specificity, diagnostic accuracies of CAD were 89%, 80%, 88% and 92%, 83%, 91%, respectively (P>0.05). ② General side effects occurred in 78% of the patients in four-minute group and in 88% of the patients in the six-minute group. The incidence of side effects in the two groups was not significantly different. Conclusion Four-minute adenosine infusion, in combination with perfusion tomography, has high clinical value and similar diagnostic efficacy for myocardial ischemia of CAD with the six-minute protocol, and is accepted easily by patients because of its abbreviated infusion. |
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