| 宋建华,缪競陶,解学乾.慢性心功能不全患者MSCT肺灌注成像与心功能相关性的初步探讨[J].中国医学影像技术,2007,23(11):1628~1632 |
| 慢性心功能不全患者MSCT肺灌注成像与心功能相关性的初步探讨 |
| Multi-slice computed tomography pulmonary perfusion imaging and clinic cardiac function in patients with chronic cardiac insufficiency: a preliminary correlative study |
| 投稿时间：2007-04-16 修订日期：2007-09-14 |
| DOI： |
| 中文关键词: 灌注成像 肺脏 心功能不全 达峰时间 |
| 英文关键词:Perfusion imaging Pulmonary Chronic cardiac insufficiency Time to peak |
| 基金项目: |
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| 摘要点击次数: 1942 |
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| 中文摘要: |
| 目的 探讨慢性心功不全(CCI)患者MSCT肺灌注成像(MSCT-PPI)与临床心功能的相关性。方法 我院住院治疗的CCI患者24例为CCI组,其中心功能Ⅰ级8例、Ⅱ级7例、Ⅲ级9例。正常成人对照组共28例。对所有对象的上下两个肺野行MDCT-PPI扫描,在胸膜下肺野12个区域设置兴趣区,获得兴趣区首过期时间-密度曲线(TDC),并取强化峰值(PE)、强化增量(PEI)、强化起始时间(TTE)、达峰时间(TTP)、首过时间(TFP)进行统计对照分析。结果 肺实质灌注量化参数PE、PEI在24例CCI组三个级别间及其与对照组间无统计学差异。肺实质灌注时相参数TTE、TTP、TFP在CCI组三个级别间存在显著统计学差异(P＝0.001);其中TTP在心功能不全组三个级别分别为(17.3±1.0)s、(20.6±2.0)s、(23.8±2.7)s,三个级别间存在显著统计学差异(P＝0.001);正常组为(18.6±1.6) s,Ⅱ、Ⅲ级组与对照组存在显著统计学差异(P＜0.05);Ⅰ级组与对照组间无统计学差异。各组时相参数数据均与CCI程度显著相关。结论 对慢性心功能不全24例行MSCT-PPI表明,肺实质血流灌注时相延迟与心功能分级具有显著相关性,有助于心功能异常诊断及分级。肺血流灌注量变化对本研究中心功能不全患者的判断无显著意义。 |
| 英文摘要: |
| Objective To explore the correlation between the MSCT-PPI and clinic cardiac function in patients with CCI. Methods Twenty-four patients who were in hospital during Oct. 2005 to Apr.2006 at department of cardiac surgery for chronic cardiac insufficiency (CCI) were chosen as CCI group, including 8 patients of CCI grade Ⅰ, 7 patients of grade Ⅱ, 9 patients of grade Ⅲ. Twenty-eight normal candidates were selected as control group. All of them were examined by MDCT-PPI to get contrast media first pass time-density curve (TDC) in the upper and lower lung field and 12 regions of interests were placed in subpleural parenchyma to calculate PE, PEI, TTE, TTP, TFP. Statistical analysis and comparison was performed among CCI groups and control group. Results Comparison of pulmonary parenchyma perfusion quantizing parameter: no statistical difference was found among CCI groups and control group in PE and PEI. Comparison of pulmonary parenchyma perfusion phase parameter: statistical difference was found among these groups (P=0.001) in TTE,TTP, TFP. And TTP of three CCI groups were (17.3±1.0) s, (20.6±2.0) s, (23.8±2.7) s respectively, and statistical difference was found among these groups of CCI (P=0.001) in TTP; TTP of control group was (18.6±1.6) s, and the groups of grade Ⅱand grade Ⅲ were statistical different from control group (P＜0.05) and no statistical difference was found between grade Ⅰgroup and control group in TTP. All of the phase parameters were correlative significantly and statistically to clinic cardiac function grade. Conclusion MDCT-PPI of 24 CCI patients indicated that the phase parameters (TTE,TTP) of CCI were delayed and correlative to the clinic cardiac function grade significantly and statistically. It’s helpful to diagnose and grade assessment on CCI with these phase parameters. And the pulmonary perfusion quantification parameters had no statistical sense on diagnosing and assessing CCI in this study. |
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