| 杨开颜,蒋涛,王钺,翟仁友.氢质子磁共振波谱在乳腺病变中的应用价值[J].中国医学影像技术,2007,23(11):1618~1621 |
| 氢质子磁共振波谱在乳腺病变中的应用价值 |
| Clinical value of 1H-MRS in breast disease |
| 投稿时间：2007-03-22 修订日期：2007-09-01 |
| DOI： |
| 中文关键词: 乳腺疾病 乳腺肿瘤 磁共振波谱学 |
| 英文关键词:Breast disease Breast neoplasms Magnetic resonance spectroscopy |
| 基金项目: |
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| 摘要点击次数: 2147 |
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| 中文摘要: |
| 目的 研究乳腺氢质子磁共振波谱(1H-MRS)的代谢特征,判断其在鉴别乳腺良、恶性病变中的应用价值。 方法 回顾性分析有明确病理结果的57例乳腺病变(恶性32例,良性25例)及12例正常腺体的1H-MRS的代谢特征。 结果 32例恶性病变中有15例于3.23 ppm处出现Cho峰(SNR≥2),12例Cho峰为阴性,有5例采集失败,不能确定有无Cho峰。25例良性病变中,有2例在3.23 ppm处出现Cho峰(SNR＜2),3例采集失败,另外20例良性病变及12例正常腺体中均未探及Cho峰。以Cho峰鉴别良恶性病变的平均敏感性为55.6 ％±7.1%,特异性为100％,准确性75.5％±6.1%,阳性预测值为100％,阴性预测值为64.7％±6.8%。Kappa＝0.529±0.104,P＝0.000＜0.05,有统计学意义。 结论 1H-MRS在鉴别乳腺良、恶性病变中有一定的实用价值,但由于影响因素较多,目前敏感性较低,其临床应用价值有待进一步研究。 |
| 英文摘要: |
| Objective To study the 1H-MRS metabolic features of breast diseases and assess the clinical usefulness in distinguishing benign from malignant lesions. Methods Analyze retrospectively the 1H-MRS metabolic features of 57 breast diseases (32 malignant and 25 benign) confirmed by pathology and 12 normal breast. Results Spectroscopy findings were positive in 15 of 32 carcinomas (show increased choline resonance peak at 3.23 ppm, SNR≥2) but negative for all benign lesions and normal breast. Eight cases were (5 malignant and 3 benign) failed (ie, determination of positive or negative of choline could not be made).The mean sensitivity and specificity were 55.6%±7.1% and 100% respectively, mean accuracy was 75.5％±6.1%, and positive predictive value was 100%, the negative predictive value was 64.7%±6.8%. Kappa＝0.529±0.104, P＝0.000＜0.05. Conclusion 1H-MRS is useful in distinguishing benign from malignant lesions, but the sensitivity of choline is low owe to many influencing factors now. The clinical value of spectroscopy want to be study further. |
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