| 齐丽萍,张晓鹏,唐磊,孙应实,汪宁.扩散加权成像用于中央型肺癌与肺不张鉴别的初步研究[J].中国医学影像技术,2007,23(10):1486~1490 |
| 扩散加权成像用于中央型肺癌与肺不张鉴别的初步研究 |
| Diffusion-weighted MR imaging for differentiation diagnosis of central lung cancer from postobstructive lobar collapse-preliminary study |
| 投稿时间：2007-06-18 修订日期：2007-08-16 |
| DOI： |
| 中文关键词: 磁共振成像 扩散加权成像 肺不张 体层摄影术,X线计算机 |
| 英文关键词:Magnetic resonance imaging Diffusion-weighted imaging Atelectasis Tomography, X-ray computed |
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| 中文摘要: |
| 目的 探讨扩散成像用于鉴别中央型肺癌与阻塞性肺不张的可行性及与常规的T1WI,T2WI,STIR序列和增强CT间鉴别能力进行比较。方法 对33例中央型肺癌合并阻塞性肺不张的病例进行前瞻性研究。全部病例均经病理证实诊断。采用GE 1.5T超导磁共振机检查。扫描序列包括: SE-TIWI、FRFSE-T2WI、STIR、扩散加权成像(DWI), b=0,500 s/mm2,4个NEX,分次屏气扫描。CT检查采用GE 64排CT,常规增强扫描,扫描时间为注药后28~30 s。结果 扩散加权图像基本上能满足诊断需要,33例中32例可用于研究。DWI图像对肺癌、肺不张的鉴别能力优于T1WI及增强CT(P<0.05); DWI、T2WI及STIR三种序列间鉴别能力无显著性差异(P>0.05);7个T2WI无法鉴别的病例在DWI能够鉴别,联合T2WI与DWI鉴别能力明显高于单独运用T2WI。DWI图像的信号强度比明显高于T2W和STIR;DWI图像的对比噪声比高于T2WI,与STIR图像无明显差别。扩散图像上肺癌的信号强度高于肺不张(P<0.001);肺癌的ADC值低于肺不张(P<0.001),肺癌和肺不张的ADC值分别为(1.48±0.56)×10-3s/mm2、(2.91±0.66)×10-3s/mm2。结论 扩散成像可用于鉴别中央型肺癌与肺不张,并且是T2WI的有效补充。 |
| 英文摘要: |
| Objective To investigate if diffusion-weighted MR imaging (DWI) is useful for differentiating central lung cancer from postobstructive lobar collapse and compare its ability with routine MR sequences and CT. Methods Thirty-three cases that had diagnosed to be central lung cancer with atelectasis by CT underwent MRI examination of the thorax. All lesions were proved pathologically. MR examinations were done at 1.5T MR. Scan sequences were as followed, SE-TIWI, FRFSE-T2WI, STIR and DWI with b=0, 500 s/mm2, 4 NEX and breath holding. Contrast-enhanced CT examinations were done 28-30 seconds after injection of nonion contrast agents at GE 64-detector row CT. Results Most DWI images (32/33) were good enough to satisfy the need of analysis. The differentiation ability of DWI was superior to that of T1WI and contrast-enhanced CT, but there was no difference between DWI, T2WI and STIR. Seven cases who had not be distinguished on T2WI could clearly be differentiated on DWI images. The differentiation ability of combining T2WI and DWI was better than that of T2WI single. The signal-intensity ratio of DWI was higher than that of T2WI and STIR. The contrast-noise ratio of DWI was higher than T2WI and equal to that of STIR. The mean signal intensity of tumors was higher than that of atelectasis on DWI images (P<0.001). The mean ADC value of lung cancer was significantly lower than that of collapse lung tissues, (1.48±0.56)×10-3s/mm2 and (2.91±0.66)×10-3s/mm2s/mm2 respectively. Conclusion DWI can be used to differentiate central tumor from postobstructive lobar collapse and it is effective replenish of T2WI. |
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