| 于东升,杨仁杰,曲巍立,李子祥.经皮微波和碘-125粒子联合治疗VX2兔肝癌的实验研究[J].中国医学影像技术,2007,23(9):1263~1266 |
| 经皮微波和碘-125粒子联合治疗VX2兔肝癌的实验研究 |
| Exploratory study of percutanous microwave coagulation therapy for liver cancer by combining 125I seed brachytherapy in a rabbit VX2 tumor model |
| 投稿时间：2007-03-19 修订日期：2007-04-29 |
| DOI： |
| 中文关键词: 肝肿瘤 微波 125I粒子源 体层摄影术,X线计算机 模型,动物 |
| 英文关键词:Liver neoplasms Microwave 125I seed Tomogrophy, X-ray computed Animal, model |
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| 中文摘要: |
| 目的 探讨微波或碘-125粒子治疗兔VX2肝癌与两者联合治疗的不同疗效。方法 将80只单点种植VX2肝癌瘤株的新西兰大白兔,B超动态监测肿瘤大小2 cm时,随机分入四组,每组20只,A组,微波治疗组(40 W功率作用2 min);B组,碘-125粒子治疗组(0.5 mCi,肿瘤周边处方剂量60 Gy);C组,微波和碘-125粒子联合治疗组;D组,未治疗的对照组。治疗前均行CT平扫及增强扫描,制定治疗计划,A组、B组和C组在CT引导下经皮穿刺治疗兔VX2肝癌,治疗后两天摄腹部平片验证,三周末切除肿瘤标本测量肿瘤体积大小,进行统计学分析,同时取肿瘤组织制成病理切片,分别采用HE染色,观察其病理变化,并取肿瘤在电镜下观察其超微结构变化。结果 A组,肿瘤体积大小为(33.6±12.3) cm3, B组,肿瘤大小为(35.1±13.2) cm3, C组,肿瘤大小为(6±2.3) cm3,C组联合治疗组与A组微波治疗组和B组碘-125粒子治疗组比较有统计学意义(P<0.05)。D组,肿瘤大小为(198.1±72.1) cm3,治疗组(A组、B组和C组)与未治疗的对照组(D组)比较亦有明显的统计学意义(P<0.01)。结论 经皮微波和碘-125粒子联合治疗兔VX2肝癌,可以弥补单独治疗组的不足,疗效可靠,是一种新的有效的联合治疗手段。 |
| 英文摘要: |
| Objective This study was undertaken to explore a combination therapy with percutanous microwave coagulation therapy (PMCT) and 125I seed brachytherapy for liver cancer, to determine if it can increase the therapy efficiency compared with PMCT alone or 125I seed brachytherapy alone in a Rabbit VX2 tumor Model. Methods Eighty New Zealand white rabbits were implanted with VX2 tumor in the deep aspect of the left lobe of liver.After monitoring with B-ultrasound that 2 cm diameter tumors were observed, rabbits were classified into four groups.Initially, tumor were treated with (a) PMCT (power at 40 W for 2 minutes) alone, (b)125I seed brachytherapy alone.The activity of per seed was 0.5 mCi.The peripheral radiation total dose was 60 Gy, (c) the combination therapy with PMCT and 125I seed brachytherapy, (d) no treatment. The rabbits were examined by CT for plan before treatment.(a),(b) and (c) CT-guide percutanous treatment and taken plain film for prove the plan after 2 days after treatment. Tumors were measured after 3 weeks treatment by excision and done pathologic examination with H＆E dye and done electron microscope examination.Results Mean volume for treated tumors were as following: (a) (33.6±12.3) cm3, PMCT alone; (b) (35.1±13.2) cm3, 125I seed brachytherapy alone; (c)(6±2.3) cm3, the combination therapy (P<0.05, compared with PMCT alone or 125I seed brachytherapy alone); (d)(198.1±72.1) cm3,no treatment (P<0.01, compared with treatment group a,b and c). Conclusion The combination therapy with PMCT and 125I seed brachytherapy for liver cancer in the rabbit VX2 tumor model is a new combination therapy with good effect by making up the deficiency of PMCT alone or 125I seed brachytherapy alone. |
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