| 刘宇杰,田家玮.QTVI评价急性白血病化疗前后左室收缩功能的临床研究[J].中国医学影像技术,2007,23(7):1019~1021 |
| QTVI评价急性白血病化疗前后左室收缩功能的临床研究 |
| Left ventricular myocardial systolic function before and after chemotherapy in patients with acute leukemia by quantitative tissue velocity imaging |
| 投稿时间：2007-01-28 修订日期：2007-06-09 |
| DOI： |
| 中文关键词: 定量组织速度成像 Simpson法 收缩功能 左室 急性白血病 |
| 英文关键词:Quantitative tissue velocity imaging Simpson method Systolic function Left ventricular Acute leukemia |
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| 中文摘要: |
| 目的 应用2-DE和QTVI技术检测白血病患者化疗前、后左室收缩功能,评价柔红霉素(DNR)对急性白血病患者早期心功损害情况。方法 病例组选急性白血病患者16例,对照组选正常人23例。应用Simpson及QTVI两种方法检测左室整体收缩功能,对比二者对DNR心肌毒性的检测能力。结果 化疗前病例组与正常组比较无统计学意义。用Simpson法检测药物不同累积剂量左室功能未见异常;QTVI检测中等剂量时发现左室侧壁及前间隔收缩期峰值流速(VS)较化疗前减低。结论 QTVI能定量评价左室整体收缩功能,检出DNR损害左室功能较Simpson法更敏感,可为临床提供一种早期检测心肌功能的新方法。 |
| 英文摘要: |
| Objective The diagnostic value of two-dimensional echocardiography (2-DE) and quantitative tissue velocity imaging (QTVI) were compared in left ventricular myocardial systolic function before and after chemotherapy in patients with acute leukemia. Methods Sixteen patients in case group were confirmed by bone marrow aspiration, twenty-three normal subjects were in control group. Ejection fraction (EF) and stroke volume (SV) were measured by the method of Simpson. Peak velocity during systole (VS) was measured at the mitral annular level in three apical longitudinal views using QTVI. The parameters of left ventricular systolic function acquired by the method of Simpson and QTVI were compared. Results The myocardial systolic function had no obviously difference between control and case groups before chemotherapy. The method of Simpson had no positive results in detecting left systolic function in the study. However, VS was decreased in left ventricular lateral wall and anterior septum of mitral annulus detected by QTVI. Conclusion QTVI can evaluate the integral myocardial systolic function quantitatively and monitor the changes of myocardial function after chemotherapy. The diagnostic sensitivity of QTVI on myocardial function is higher than the Simpson method. |
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