| 倪红艳,王明时,VoykoKavcic,JianhuiZhong,祁吉.健康老年人和阿尔茨海默病人脑白质改变的扩散张量成像研究[J].中国医学影像技术,2007,23(7):971~975 |
| 健康老年人和阿尔茨海默病人脑白质改变的扩散张量成像研究 |
| Changes of white matter in aging and early Alzheimer's disease by diffusion tensor imaging |
| 投稿时间：2007-06-20 修订日期：2007-06-30 |
| DOI： |
| 中文关键词: 磁共振成像 扩散张量成像 阿尔茨海默病 老年人 |
| 英文关键词:Magnetic resonance imaging Diffusion tensor imaging Alzheimer's disease Aging |
| 基金项目: |
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| 中文摘要: |
| 目的 应用扩散张量成像(DTI)研究健康老年人(ON)和早期阿尔茨海默(AD)病人脑白质改变的情况。方法 对20例中青年健康志愿者(YN组),18例ON,14例AD进行DTI扫描,在9个感兴趣区(ROI)测量并比较五个DTI参数:各向异性分数(FA)、平均扩散系数(〈D〉)和扩散张量本征值(λ1、λ2、λ3)。结果 与YN组相比,ON组的〈D〉、λ1、λ2和λ3在所有ROI均有提高,FA仅在胼胝体膝部和体部(CCM)降低(P<0.05)。与ON组相比,AD病人显示在胼胝体压部(CCP)的〈D〉提高、在CCP和后顶-颞叶皮层下白质FA显著降低、在CCM的λ1提高、在CCP的λ3提高(P<0.05)。结论 DTI显示有较强的由年龄引起的脑白质变化,早期AD病人存在额外的脑白质结构异常。DTI的不同测量参数在检测脑白质变化中具有不同的敏感性。 |
| 英文摘要: |
| Objective To investigate the effects of aging and early stage Alzheimer's disease (AD) on white matter (WM) integrity using diffusion tensor imaging (DTI). Methods DTI was performed with 20 young and middle age subjects (YN), 18 elder subjects (ON) and 14 mildly impaired AD patients. Fractional anisotropy (FA), mean diffusivity (〈D〉), and three eigenvalues (λ1, λ2, and λ3) values were computed and compared on 9 regions of interest (ROI). Results Compared with YN, ON showed that 〈D〉, λ1, λ2 and λ3 significantly increased in all ROIs and FA, however, significant decreased only in genu and body (CCM) of corpus callosum (CC). AD patients as compared with old controls, showed significant decrease in FA in the parietal-temporal subcortical WM and the posterior CC (CCP), significant increase in λ1 in CCM, and significant increase 〈D〉 and λ3 in CCP. Conclusion Results showed robust age-related effects on WM change. AD patients have additional WM alterations. Different DTI indices have different sensitivity in detection of WM integrity. |
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