| 姜慧杰,徐克,张慧博,刘白鹭,舒圣捷,黄亚华.多层螺旋CT灌注成像活体评价肝VX2移植瘤新生血管生成[J].中国医学影像技术,2007,23(7):967~970 |
| 多层螺旋CT灌注成像活体评价肝VX2移植瘤新生血管生成 |
| In vivo assessment of neovascularization of rabbit VX2 liver tumor by multi-slice CT perfusion |
| 投稿时间：2007-01-16 修订日期：2007-06-24 |
| DOI： |
| 中文关键词: 体层摄影术,X线计算机 灌注成像 参数 VX2肿瘤 新生血管形成 |
| 英文关键词:Tomography, X-ray computed Perfusion imaging Parameters VX2 tumor Neovascularization |
| 基金项目:黑龙江省教育厅科学技术研究项目(11511181);黑龙江省自然基金资助项目(D2006-07)。 |
|
| 摘要点击次数: 2330 |
| 全文下载次数: 1609 |
| 中文摘要: |
| 目的 应用多层螺旋CT灌注技术研究兔肝VX2移植瘤新生血管生成。方法 选取10只正常新西兰大白兔肝脏,以及15只种有肝VX2移植瘤的兔肝脏行多层螺旋CT灌注扫描,对比肿瘤边缘区、非肿瘤区肝脏、正常肝脏的肝血流量(HBF)、血容积(HBV)、平均通过时间(MTT)、毛细血管表面通透性(PS)和肝动脉灌注指数(HAI)的变化规律。结果 肿瘤边缘区HBF、HBV、HAI、PS增高与非肿瘤区肝脏和正常肝脏相比有统计学差异(P<0.05)。肿瘤边缘区MTT降低与非肿瘤区肝组织和正常肝脏相比有统计学差异(P<0.05)。各灌注参数在非肿瘤区肝脏和正常肝脏中无显著差异(P>0.05)。结论 多层螺旋CT灌注成像能活体评价肝VX2移植瘤新生血管生成,提供量化功能信息。 |
| 英文摘要: |
| Objective To study the neovascularization of rabbit VX2 liver tumor using multi-slice computed tomography (MSCT) perfusion. Methods Perfusion CT images were obtained in 10 normal New Zealand rabbits and 15 rabbits with VX2 liver tumors. The various perfusion parameters were measured in the rim of the tumor, non-tumorous regions in the liver and the normal liver. Results The increased HBF, HBV, HAI, PS and the decreased MTT in the rim of the tumor were differed from the non-tumorous regions in the liver and the normal liver (P<0.05). All the parameters between non-tumorous regions in the liver and the normal liver had no differences (P>0.05). Conclusion Perfusion CT is a method for studying neovascularization in vivo and provides quantitative functional information. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
