| 赵云辉,许乙凯.磁化传递对比磁共振成像在诱发性大鼠肝硬化肝癌中的初步应用研究[J].中国医学影像技术,2007,23(7):963~966 |
| 磁化传递对比磁共振成像在诱发性大鼠肝硬化肝癌中的初步应用研究 |
| Primarily role of magnetization transfer contrast MR imaging for the rat with cirrhosis and HCC induced by DENA |
| 投稿时间：2007-01-16 修订日期：2007-06-15 |
| DOI： |
| 中文关键词: 大鼠 肝硬化 肝细胞癌 磁化传递对比 磁共振成像 |
| 英文关键词:Rat Cirrhosis Hepatocellular carcinoma Magnetization transfer contrast Magnetic resonance imaging |
| 基金项目: |
|
| 摘要点击次数: 2809 |
| 全文下载次数: 3077 |
| 中文摘要: |
| 目的 初步探讨磁化传递对比(MTC)磁共振成像(MRI)技术在诱发性大鼠肝硬化肝癌中的作用。方法 二乙基亚硝胺溶液诱发的大鼠肝硬化肝癌模型16只,结合病理检查发现>5.0 cm的癌结节66个,对照组为10只正常Wister大鼠。所有大鼠均行附加MT脉冲前后MRI扫描,序列包括SE序列T1WI、FSE序列T2WI。测量MR图像上正常肝组织、硬化肝脏及肝癌组织附加MT脉冲前后的的信号强度,计算信噪比(SNR)、对比噪声比(CNR)及磁化传递率(MTR)。结果 SE序列T1WI上,附加MT脉冲后正常肝实质信号强度降低,SNR低于无MT脉冲图像(P＝0.002);肝硬化组织附加MT后信号强度显著下降,SNR明显低于无MT时(P＝0.000);肝癌附加MT后SNR两者无显著差异(P＝0.334),CNR较附加MT前降低但无统计学差异(P＝0.158)。FSE序列T2WI上,正常肝实质附加MT后信号强度降低,SNR低于无MT脉冲时(P＝0.021);肝硬化附加MT后SNR显著低于无MT时(P＝0.000);肝癌附加MT脉冲前后信号强度无明显变化,SNR无统计学差异(P＝0.549),CNR较附加MT前增高,但两者间无显著差异(P＝0.205)。SE序列T1WI上,肝硬化MTR显著高于正常肝实质及肝癌(P＝0.001);正常肝实质与肝癌MTR类似(P＝0.788)。FSE序列T2WI上,硬化肝组织的MTR较正常肝实质及肝癌明显增高(P＝0.002;P＝0.000);正常肝实质与肝癌的MTR无统计学差异(P=0.352)。结论 FSE序列T2WI附加MT脉冲图像上肝硬化组织信号降低,而肝癌信号强度变化不明显,对比度提高,有利于肝硬化背景上肝癌病灶的检出和显示。 |
| 英文摘要: |
| Objective To primarily discuss the application value of magnetization transfer contrast (MTC) magnetic resonance imaging (MRI) for the rats with cirrhosis and hepatocellular carcinoma (HCC) induced by DENA. Methods There were sixteen rats with cirrhosis and HCC induced by DENA. Sixty-six nodes of HCC were found by combining pathologic examination. Ten normal Wistar male rats that bought from the animal center of Nanfang hospital of the Nanfang medical university served as the control group. MRI with MT presaturation pulse and with non-MT were performed in each sequence in all rats. The sequences included T1-weighted spin echo (SE) imaging (repetition time /echo time , 450/15 ms) and T2-weighted fast SE images (TR/TE, 5000/128 ms). Average signal intensity (SI), adjacent hepatic parenchyma and background noise (N) were measured on MR images. Signal to noise ratio (SNR), contrast to noise ratio (CNR) of lesions and liver and MT ratio (MTR) were calculated on all images. Results On T1WI, the SI decreased on images with MT and SNR of images with MT were lower than the images with non-MT in normal liver (P=0.002). The SI of cirrhosis was obviously decreased on MT images and SNR was significant difference than non-MT images (P=0.000). In HCC, SNR of T1WI with MT was slightly lower than non-MT images but was no significant difference between the two groups (P=0.158). On T2WI, the SI of normal liver with MT was lower than non-MT and SNR was significant lower than non-MT (P=0.021). In cirrhosis liver, SNR of T2WI with MT images was remarkably low than non-MT (P=0.000). The SI of HCC on T2WI with MT images was similar to non-MT and SNR was no significant difference between MT and non-MT images (P=0.549), while CNR was higher than non-MT but was no statistical significance between the two groups (P=0.205). MT ratio (MTR) of cirrhosis was significant higher than the normal liver and HCC (P=0.000), while MTR of normal liver was similar to HCC (P=0.788) on T1WI. On T2WI, MTR of cirrhosis was remarkably higher than the normal (P=0.002) and HCC (P=0.000), while MTR was no significant difference between the normals and the HCCs (P=0.352). Conclusion The contrast of HCC with the adjacent hepatic parenchyma was improved due to the signal intensity of surrounding cirrhotic tissue decreased. The sequence of FSE-T2WI with MT was in favor of in the detection and charactezation of HCC in cirrhotic background. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
