| 王琦,时高峰,杜煜,王亚宁,杨丽,李月考.正常肝脏与微小转移性肝癌多层螺旋CT灌注成像的临床研究[J].中国医学影像技术,2007,23(6):877~880 |
| 正常肝脏与微小转移性肝癌多层螺旋CT灌注成像的临床研究 |
| Clinical study of muti-slice CT perfusion imaging in normal liver and small metastatic liver cancer |
| 投稿时间：2006-11-06 修订日期：2007-05-08 |
| DOI： |
| 中文关键词: 肝肿瘤 转移 灌注 体层摄影术,X线计算机 |
| 英文关键词:Liver neoplasms Metastasis Perfusion Tomography, X-ray computed |
| 基金项目:河北省科技厅资助项目(05276101D-67)。 |
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| 中文摘要: |
| 目的 研究CT灌注成像在正常肝组织和微小转移性肝癌的应用价值。方法 21例肝转移癌患者选取48个微小转移灶和12例正常肝脏志愿者行多层螺旋CT灌注扫描,通过兴趣区(ROI)的时间密度曲线,应用去卷积法获得血流量(BF)、血容量(BV)、平均通过时间(MTT)、毛细血管表面通透性(PS)和肝动脉灌注指数(HAF)、肝动脉灌注量(HAP)、门静脉灌注量(PVP)等参数值。结果 正常肝组织的BF、BV、MTT、PS、HAF、HAP、PVP和IRF T0的平均值分别为(111.55±32.80)ml·min-1·100 ml-1、(22.69±2.99)ml·100 g-1、(15.73±1.74)s、(19.12±6.86) ml·min-1·100 ml-1、(16.67±6.12)%、(19±9.05) ml·min-1·100 ml-1、(92.55±27.24) ml·min-1·100 ml-1、(2.80±1.66) s。转移癌组分别为(132.44±76.87)ml·min-1·100 ml-1、(12.94±5.62)ml·100 g-1、(10.91±3.68)s、(29.12±12.90) ml·min-1·100 ml-1、(81.24±17.42)%、(90.75±47.85) ml·min-1·100 ml-1、(41.69±47.85) ml·min-1·100 ml-1、(2.09±1.58) s。转移癌组与正常肝组比较,BF、HAF、MTT、HAP、 BV和PS两组的平均值有显著性差异(P<0.05);PVP(P=0.06)和IRF T0(P=0.77)的平均值无显著性差异。结论 CT灌注成像或以检测到微小转移癌引起的血流动力学变化,CT灌注技术对于诊断微小转移癌能够提供更多的信息。 |
| 英文摘要: |
| Objective To evaluate muti-slice CT perfusion imaging in normal liver and small metastatic liver cancer. Methods Twelve cases of normal liver and 21 patients with 48 small metastases underwent CT perfusion imaging. The ROI mean values of blood flow (BF), blood volume (BV), mean transit time (MTT), permeability surface area product (PS), hepatic arterial fraction (HAF), hepatic arterial perfusion (HAP), portal vein perfusion (PVP) and IRF T0 were obtained on AW 4.2 workstation with perfusion 3 software. Results The mean values of BF, BV, MTT, PS, HAF, HAP, PVP, and IRF T0 in normal liver tissue were (111.55±32.80) ml·min-1·100 ml-1,(22.69±2.99) ml·100 g-1, (15.73±1.74) s, (19.12±6.86) ml·min-1·100 ml-1, (16.67±6.12)%, (19±9.05) ml·min-1·100 ml-1, (92.55±27.24) ml·min-1·100 ml-1, (2.80±1.66) s, respectively, while they were (132.44±76.87) ml·min-1·100 ml-1, (12.94±5.62) ml·100 g-1, (10.91±3.68) s, (29.12±12.90) ml·min-1·100 ml-1, (81.24±17.42)%, (90.75±47.85) ml·min-1·100 ml-1, (41.69±47.85) ml·min-1·100 ml-1, (2.09±1.58) s in small metastases. There was statistical significance in mean values of BF, HAI, MTT, HAP, BV and PS between small metastases and normal liver (P＜0.05). However, no significant difference was found in the mean values of PVP (P=0.06) and IRF T0 (P=0.77). Conclusion CT perfusion can detect the hemodynamic changes of small metastases, it provides more information of micrometastases for clinical diagnosis. |
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