| 杨学东,曹菊,王霄英,李晓玫,许玉峰,蒋学祥.3.0T磁共振大鼠肾脏血氧水平依赖成像的初步研究[J].中国医学影像技术,2007,23(6):809~811 |
| 3.0T磁共振大鼠肾脏血氧水平依赖成像的初步研究 |
| Blood oxygen level-dependent MR imaging of rat kidney at 3.0T MR scanner: initial experience |
| 投稿时间：2007-04-12 修订日期：2007-06-05 |
| DOI： |
| 中文关键词: 磁共振成像 肾脏 血氧水平依赖成像 |
| 英文关键词:Magnetic resonance imaging Kidney Blood oxygen level-dependent |
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| 中文摘要: |
| 目的 评价用3.0T MR行大鼠肾脏功能成像的可行性,评价R2*值在观察者间和观察者内的可重复性。方法 12只健康雄性Wistar大鼠分别行肾脏T2WI及BOLD成像,两位医师分别对T2WI及BOLD图像按照5分法进行质量评价。在T2图像上由一位医师分别测量左右肾皮髓质信噪比。使用工作站进行BOLD图像重建,由两位医师分别独立测量肾皮髓质R2*值,其中一位医师2周后再次测量。然后对测量及评价结果进行统计学处理。结果 两观察者分别认为T2WI有91.7％(11/12)和83.3％(10/12)达到5分(Kappa值0.625,P=0.02);BOLD图像两者判断分别有83.3％(10/12)和91.7％(11/12)达到4分及以上(Kappa值0.586,P=0.008)均达到测量要求。Bland-Altman分析显示观察者间和观察者自身测量皮髓质R2*值重复性较好,相关系数分别达到观察者间:0.96,0.98;观察者自身:0.97,0.98。R2*值的变异系数为皮质17.80%;髓质17.96%。结论 3.0T MR行大鼠肾脏BOLD成像所测数据在不同观察者间和同一观察者内的可重复性较好,能够用来进行肾脏功能成像的实验研究。 |
| 英文摘要: |
| Objective To evaluate the feasibility of BOLD MR imaging of rat kidney at 3.0T MR scanner and the interobserver and intraobserver reproducibility of R2* value. Methods Twelve male healthy Wistar rats were performed kidney T2WI and BOLD imaging. Two doctors evaluated the quality of the T2WI and BOLD images with 5 grades criterion. Bilateral kidney SNRs of cortex and medulla were measured on T2WI. BOLD images were reconstructed on workstation, two doctors measured the R2* values of cortex and medulla respectively and one of the two doctors measured them again 2 weeks later. The values were statistically analyzed. Results 91.7％(11/12) vs 83.3％(10/12) of T2W images scored 5 grades (Kappa value=0.625, P=0.02), and 83.3％ (10/12) vs 91.7％ (11/12) of BOLD images scored 4 grades and above (Kappa value=0.586,P=0.008) by the two observers respectively. Bland-Altman analysis showed that the intraobserver and interobserver reproducibility of R2* value was good. The correlation coefficient was: interobserver 0.96 and 0.98, intraobserver 0.97 and 0.98 for cortex and medulla respectively. Coefficient of variation between rats was 17.80% and 17.96% in cortex and medulla, respectively. Conclusion The interobserver and intraobserver reproducibility of R2* value of rat renal cortex and medulla measured at 3.0T MR is high, and it is feasible to perform functional MRI of rat kidney at 3.0T MR scanner. |
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