| 于春水,赵丽,叶静,李坤成.结节性硬化患者的脑扩散张量成像初步研究[J].中国医学影像技术,2007,23(6):785~787 |
| 结节性硬化患者的脑扩散张量成像初步研究 |
| Diffusion tensor imaging of brain in patients with tuberous sclerosis: a preliminary study |
| 投稿时间：2007-04-02 修订日期：2007-06-06 |
| DOI： |
| 中文关键词: 结节性硬化 脑 扩散张量成像 |
| 英文关键词:Tuberous sclerosis Brain Diffusion tensor imaging |
| 基金项目: |
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| 摘要点击次数: 2142 |
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| 中文摘要: |
| 目的 利用扩散张量成像(DTI)研究结节性硬化(TS)患者脑灰质和白质内病灶的扩散特点。方法 对14例临床和影像学诊断的TS患者利用3.0T MR系统进行DTI检查,测量34个皮层病灶的平均扩散率(MD)和12个白质病灶的MD、分数各向异性(FA)、最大本征值(λ1)和横向本征值(λ23),并与对侧相应部位的扩散指标比较。结果 在TS患者,皮层和白质病灶的MD明显高于对侧 (P<0.001), 白质病灶的FA明显低于对侧(P<0.001),λ23明显高于对侧(P<0.001),而λ1仅略高于对侧(P＝0.0146)。结论 DTI可提供TS患者脑灰质和白质病灶的病理信息。 |
| 英文摘要: |
| Objective To investigate diffusion features of brain gray and white matter lesions in patients with tuberous sclerosis (TS) using diffusion tensor imaging (DTI). Methods DTI was performed with a 3.0T MR scanner in 14 patients with TS who were diagnosed by clinical and radiological features. The mean diffusivity (MD) of 34 cortical lesions and the MD, fractional anisotropy (FA), primary (λ1) and transverse eigenvalue (λ23) of 12 white matter lesions were measured and compared with those of contralateral corresponding regions. Results Compared with contralateral corresponding regions, TS cortical lesions had a significant higher MD (P<0.001), TS white matter lesions had significant higher MD (P<0.001) and λ23 (P<0.001), a mild higher λ1 (P=0.0146) and a significant lower FA (P<0.001). Conclusion DTI may provide pathologic information of brain gray and white matter lesions in patients with TS. |
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