| 潘丽敏,谢君堂,张新丽,罗森林,张铁梅.基于图像灰度平均值法的多组大鼠糖刺激比较研究[J].中国医学影像技术,2007,23(4):616~619 |
| 基于图像灰度平均值法的多组大鼠糖刺激比较研究 |
| Comparison of glucose injection response in multi-group big rats based on image grey-scale average method |
| 投稿时间：2006-09-12 修订日期：2007-03-10 |
| DOI： |
| 中文关键词: 磁共振成像,功能性 灰度平均值法 大鼠 |
| 英文关键词:Magnetic resonance imaging, functional Grey-scale average method Rats |
| 基金项目:本研究为国家自然科学基金资助项目(30370432)。 |
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| 中文摘要: |
| 目的 针对于不同实验条件的6组(对照组、老年组、肥胖组、DC组、DL组、DH组)大鼠fMRI数据,分析其饮葡萄糖后在大脑下丘脑区域发生抑制反应上的特征差异。方法 在无需先验知识的情况下,利用IAM方法进行多组实验。结果 大鼠饮葡萄糖后在大脑下丘脑区域发生抑制反应,反应起始时间平均为饮葡萄糖后12.6 min;增龄造成下丘脑对糖刺激的抑制反应减退,用药可以有一定的改善作用,使其反应有所恢复,但达不到完全恢复;肥胖组大鼠下丘脑对葡萄糖刺激所致的抑制反应开始时间明显延迟,抑制程度也有所减低。结论 利用 IAM方法可以方便、快捷获取不同实验组间的差异特征,大鼠下丘脑对腹腔注射葡萄糖刺激后的抑制反应及其因喂饲条件及年龄不同所产生的差别。 |
| 英文摘要: |
| Objective Using the six groups of big rats (compare group, old group, obesity group, DC group, DL group, DH group) fMRI data to analyze the different features of the six groups of big rats after drink the glucose. Methods Without the priori knowledge, using the image grey-scale average method (IAM) to implement multi-group experiments. Results From the experimental results, after glucose loading the response in the hypothalamus was inhabit, the average start response time is 12.6 minutes, the age caused the inhabit response down, drugs can improve the condition, obviously, the start inhabit response time of obesity rat group delayed than other groups, and the response level was also low. Conclusion The IAM method is simple and convenient to detect the different features of rats, after injecting the glucose. Because of the different feed conditions and ages, the inhibit response in the hypothalamus are different. |
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