| 周滟,林富春,朱炯,陶静,李磊,路青,戈欣,范瑜,许建荣,雷皓.皮质下血管性痴呆的全脑DTI直方图分析——初步探索[J].中国医学影像技术,2007,23(4):479~481 |
| 皮质下血管性痴呆的全脑DTI直方图分析——初步探索 |
| Whole brain diffusion tensor imaging histogram analysis in subcortical vascular dementia: a primary study |
| 投稿时间：2006-10-27 修订日期：2007-03-28 |
| DOI： |
| 中文关键词: 痴呆,血管性 扩散张量成像 直方图分析 |
| 英文关键词:Dementia, vascular Diffusion tensor imaging Histogram analysis |
| 基金项目:本研究受上海市自然基金项目(06ZR14122)资助。 |
| 作者 | 单位 | E-mail | | 周滟 | 上海交通大学医学院附属仁济医院放射科,上海 200127 | | | 林富春 | 中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室,湖北 武汉 430071 | | | 朱炯 | 上海交通大学医学院附属仁济医院放射科,上海 200127 | | | 陶静 | 上海交通大学医学院附属仁济医院放射科,上海 200127 | | | 李磊 | 上海交通大学医学院附属仁济医院放射科,上海 200127 | | | 路青 | 上海交通大学医学院附属仁济医院放射科,上海 200127 | | | 戈欣 | 上海交通大学医学院附属仁济医院放射科,上海 200127 | | | 范瑜 | 上海交通大学医学院附属仁济医院放射科,上海 200127 | | | 许建荣 | 上海交通大学医学院附属仁济医院放射科,上海 200127 | xujianr@online.sh.cn | | 雷皓 | 中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室,湖北 武汉 430071 | |
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| 中文摘要: |
| 目的 探讨全脑DTI直方图分析对皮质下缺血性痴呆(SVD)患者的诊断价值。方法 对10例SVD患者和14例健康志愿者行常规MRI和扩散张量成像(DTI)检查,获得全脑平均扩散率(MD)和各向异性分数(FA)图像后,分别绘制出全脑MD和FA 直方图并对其进行分析。结果 与正常对照比较,SVD患者平均全脑MD直方图明显右移、峰高降低,其平均MD、MD直方图峰位置明显增高,而MD直方图峰高明显降低(全脑平均MD,P＝0.023;峰高,P＝0.001;峰位置,P＝0.046)。在SVD患者,全脑平均MD(r=-0.671, P=0.034)、MD直方图峰位置(r=-0.878,P=0.001)与简易智能状态检查(MMSE)评分具有显著相关性。结论 SVD患者的弥散与正常对照组明显不同,MD直方图分析可作为评价疾病严重性的指标。 |
| 英文摘要: |
| Objective To investigate the value of whole brain diffusion tensor imaging (DTI) histogram in the diagnosis of subcortical vascular dementia (SVD). Methods Conventional MRI and DTI scans were performed in 10 patients with SVD and 14 normal volunteers.After obtaining the whole brain mean diffusivity (MD) and fractional anisotropy (FA) images, the whole brain MD and FA histograms were drawn and analyzed. Results The pattern of the whole brain average MD histograms in SVD patients were different from those of control subjects. Compared with those of control subjects, the average MD histogram in patients with SVD shifted to the right with a lower peak. The average MD of the whole brain and the MD histogram peak location in patients with SVD was significantly higher than that the control group (P＝0.023, P＝0.046). But the MD histogram peak height was significantly lower than the control group (P=0.001). There were correlated between the average MD (r=-0.671, P=0.034), and the MD histogram peak location (r=-0.878, P=0.001) in patients with SVD and the mini-mental state examination (MMSE) scores. Conclusion Patients with SVD have obviously brain abnormal diffusion, and some of the MD histogram-derived measures may be used to monitor the severity of this disease. |
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