| 廖伟华,王小宜,姜新雅,王润文,邓利猛,周高峰.常规Gd-DTPA增强后脑DWI检查的可行性研究[J].中国医学影像技术,2007,23(2):205~209 |
| 常规Gd-DTPA增强后脑DWI检查的可行性研究 |
| Feasibility of diffusion-weighted imaging on brain after conventional Gd-DTPA enhancement |
| 投稿时间：2006-10-10 修订日期：2006-11-08 |
| DOI： |
| 中文关键词: 磁共振成像 扩散加权成像 钆喷替酸葡甲胺 可行性 |
| 英文关键词:Magnetic resonance imaging Diffusion-weighted imaging Gadolinium-DTPA Feasibility |
| 基金项目:本课题受国家自然科学基金资助(30370433)。 |
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| 中文摘要: |
| 目的 探讨常规增强扫描之后行DWI检查的可行性。方法 采用西门子1.5T超导型MR扫描系统对86例颅内病变患者进行检查,先行常规T1WI、 T2WI及DWI(b=0、1000 s/mm2)横断面扫描,然后行常规增强T1WI扫描,对比剂为钆喷替酸葡甲胺(Gd-DTPA),剂量为0.1 mmol/kg,注药速度为1 ml/s,注入对比剂4 min后以相同的参数再行一次DWI扫描,将增强前后的DWI原始图像均输入工作站获得表观弥散系数图。分别计算出肿瘤强化实质区、坏死囊变区、脑梗死区、正常脑灰质区、正常脑白质区,正常神经核团区域增强前后的DWI信号噪声比(SNR)、对比噪声比(CNR)、ADC值。采用配对t检验比较不同区域增强前、后SNR 、CNR及ADC值的差别。结果 正常脑组织DWI的SNR和ADC值于增强前后均无明显差别,P>0.05;增强前后肿瘤强化实质区、囊变坏死区、脑梗死DWI的SNR、CNR以及ADC值的差别也无统计学意义(P>0.05)。结论 常规Gd-DTPA增强4 min后,正常脑组织和不同的病变组织的DWI(b=0、1000 s/mm2)SNR、CNR及ADC值无明显改变,常规Gd-DTPA增强4 min后行脑DWI(b=0、1000 s/mm2)扫描是可行的。 |
| 英文摘要: |
| Objective To assess the feasibility of diffusion-weighted imaging (DWI) on brain after conventional Gd-DTPA enhancement scanning. Methods Eighty-six patients who were verified various brain lesion were examined. DWI was obtained using single-shot echo-planar imaging with b value of 0, 1000 s/mm2 before enhancement scanning. Patients were injected with Gd-DTPA (0.1 mmol/kg body weight; 1 ml/s). Repetition of DWI was obtained 4 minutes later when conventional enhancement scanning was finished. We examined the signal-to-noise ratio (SNR) of the normal brain tissues and various brain lesions and evaluated the contrast-to-noise ratio (CNR) of each lesion. In addition, the ADC values calculated from the DWI images were compared before and after administration of Gd-DTPA. The statistical significance of differences between precontrast and postcontrast administration was determined by use of a paired t test. Results The SNR and CNR of the DWI were not significantly different before and after administration of Gd-DTPA (P>0.05). There were no significant differences of ADC value before and after administration of Gd-DTPA in the normal brain tissues, and even in lesions with enhancing parenchymatou tissues or necrosis/cyst regions, infarct regions (P>0.05). Conclusion There was no significant difference before and after administration of Gd-DTPA in the SNR or CNR of DWI and ADC value. This indicates the feasibility of DWI (b=0, 1000 s/mm2) on brain after conventional enhancement scanning in clinical practice. |
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