| 吴元魁,许乙凯,刘国清,贾铭,廖昕,陈卫国.皮下应用HSA-Gd-DTPA的磁共振淋巴造影初步研究[J].中国医学影像技术,2007,23(2):191~193 |
| 皮下应用HSA-Gd-DTPA的磁共振淋巴造影初步研究 |
| MR lymphography with subcutaneous administration of HSA-Gd-DTPA: an initial study in rabbits |
| 投稿时间：2006-07-31 修订日期：2006-12-29 |
| DOI： |
| 中文关键词: 白蛋白,钆 造影剂 淋巴结 肿瘤 磁共振成像 |
| 英文关键词:Albumin, Gd Contrast media Lymph nodes Neoplasms Magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 初步探索皮下应用HSA-Gd-DTPA的磁共振淋巴造影的正常磁共振表现及信号强度-时间曲线。方法 健康新西兰兔10只,体重2.0~2.5 kg。仰卧位固定兔子,轴位和矢状位扫描双侧腘窝淋巴结。平扫序列包括T1WI、脂肪抑制T1WI和T2WI。增强扫描:平扫后双侧后肢趾蹼间隙各注射0.5 ml 0.20 mmol Gd/L的HSA-Gd-DTPA后第3、6、12、24和48 h行T1WI和T1WI FS扫描。相关参数与平扫时相同。测量增强前后淋巴结的信号强度并计算淋巴结的强化率(E%),用以绘制腘窝淋巴结的信号强度-时间曲线。结果 淋巴结平扫时呈T1WI等信号、T2WI高信号;增强扫描时淋巴结和淋巴管呈明显均匀强化。增强后第3小时,T1WI和T1WI FS像上腘窝淋巴结的E%分别为40.7％和42.8％,在第6小时,分别为75.6％和79.7％。最大强化出现在第24小时,E%分别为215.4％和232.4％。至第48小时,腘窝淋巴结的E%仍接近100％。结论 皮下间隙应用HSA-Gd-DTPA 12~48 h内的MR淋巴造影可清晰显示淋巴结和淋巴管,有望用于淋巴系统疾病的影像评估。 |
| 英文摘要: |
| Objective To investigate preliminarily the normal appearances of MR lymphography with subcutaneous administration of HSA-Gd-DTPA and the signal intensity time course. Methods Ten healthy New-Zeanland rabbits weighted at 2.0-2.5 kg were enrolled in this study. The rabbits were in the supine position when the popliteal lymph nodes were scanned in the axial and sagittal planes. T1-weighted (TR/TE=539/14 ms), T1-weighted fat suppressed (TR/TE=539/14 ms), and T2-weighted (TR/TE=2234/85 ms) spin-echo (SE) images of the lymph nodes were obtained before contrast agent administration, and T1WI images were obtained 3 h, 6 h, 12 h, 24 h and 48 h after subcutaneous injection of 0.5 ml 0.20 mmol Gd/L HSA-Gd-DTPA into the interdigital skin folds of bilateral hind limb respectively. Post-contrast MR images were obtained in the same imaging planes as pre-contrast images with identical scan parameters. The signal intensities of popliteal lymph node were measured on unenhanced images and enhanced ones, and the enhancing rates(E%) were calculated to draw the signal-time course curve. Results On unenhanced images, the lymph node appeared to be iso-intensity or slight hyper-intensity on T1WI (or T1WI FS) and hyper-intensity on T2WI. On enhanced images, the lymph nodes and lymphatic vessels showed remarkable homogeneous enhancement. The E% was 40.7% and 42.8% at the 3rd hours, 75.6% and 79.7% at the 6th hours on the T1WI and T1WI FS images respectively. The peak enhancement occurred at the 24th hours with the enhancing rate of 215.4% and 232.4% on T1WI and T1WI FS respectively. The enhancement effect was still remarkable at the 48th hours with the E% closed to 100%. Conclusion MR lymphography could display both lymph nodes and lymphatic vessels clearly during the 12-48 h period after subcutaneous injection of HSA-Gd-DTPA at the dose of 0.1 mmol HSA-Gd-DTPA per limb, and the technique might be applied in the imaging evaluation of lymphatic diseases. |
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