| 吴蓉,胡兵,姜立新,朱玲.高强度聚焦超声治疗裸鼠卵巢癌皮下移植瘤的初步观察[J].中国医学影像技术,2007,23(1):31~33 |
| 高强度聚焦超声治疗裸鼠卵巢癌皮下移植瘤的初步观察 |
| Preliminary observation for high intensity focused ultrasound in the treatment of subcutaneous ovarian cancer of nude mice |
| 投稿时间：2006-09-04 修订日期：2006-11-18 |
| DOI： |
| 中文关键词: 高强度聚焦超声 裸鼠 卵巢癌 移植瘤 |
| 英文关键词:High intensity focused ultrasound Nude mice Transplanted tumor Ovarian neoplasms |
| 基金项目: |
|
| 摘要点击次数: 2073 |
| 全文下载次数: 1196 |
| 中文摘要: |
| 目的 观察高强度聚焦超声(HIFU)治疗裸鼠卵巢癌皮下移植瘤的病理变化。方法 将12只接种人卵巢癌细胞株SKOV3的裸鼠,当肿瘤体积达1.0 cm3左右时,采用HIFU照射治疗肿瘤的外侧约1/2。于治疗后即刻和治疗后2周分别观察病理变化。结果 镜下见靶区内肿瘤组织完全凝固性坏死。结论 HIFU能够有效治疗裸鼠卵巢癌皮下移植瘤,可望成为治疗卵巢癌有前途的新方法。 |
| 英文摘要: |
| Objective To observe the pathological changes of ovarian cancer in a nude mouse model using high-intensity focused ultrasound(HIFU). Methods A total of 12 female athymic nude mice were inoculated at hip subcutaneously with SKOV3 human ovarian cancer cells. When the average tumor volume was about 1.0 cm3, the outer half of tumor was treated using high-intensity focused ultrasound. The changes of pathology was observed after treatment immediately and after 2 weeks. Results Histological examination confirmed a complete coagulation necrosis in treated region. Conclusion HIFU had the powerful effect of accurately destroying ovary tumor in a nude mouse model. HIFU has the potential to serve as a treatment for ovarian cancer. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
