| 李振伟,胡道予,夏黎明,王承缘,胡军武,冯定义.化学位移成像监控MR引导乙酸注射治疗兔VX2肿瘤的实验研究[J].中国医学影像技术,2007,23(1):5~8 |
| 化学位移成像监控MR引导乙酸注射治疗兔VX2肿瘤的实验研究 |
| Chemical-shift MR imaging of acetic acid during MR-guided percutaneous chemical ablation therapy: experimental study |
| 投稿时间：2006-08-20 修订日期：2006-11-14 |
| DOI： |
| 中文关键词: 化学位移 磁共振成像 乙酸 VX2肿瘤 |
| 英文关键词:Chemical-shift Magnetic resonance imaging Acetic acid VX2 tumor |
| 基金项目:本课题受国家"十五"科技攻关项目([2004]338号)和同济医院人才基金 基金资助。 |
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| 中文摘要: |
| 目的 探讨化学位移成像在MR引导下VX2兔行经皮穿刺乙酸化学消融的应用价值。方法 制备18只肝VX2瘤兔,在1.5T磁共振扫描仪引导下,应用FRFSE T2WI化学位移成像完成实验模型及经皮肝穿刺乙酸化学消融VX2瘤兔术中的扫描。结果 50%乙酸注射的相关部位信号明显的增加。在对VX2瘤兔行经皮肝穿刺乙酸化学消融时,化学位移成像乙酸弥散范围(最大层面)与大体标本肿瘤的坏死范围(最大层面)存在显著的正相关性(r=0.936)。结论 化学位移成像能够用于监控MR引导化学消融肝肿瘤时乙酸的分布。 |
| 英文摘要: |
| Objective To study the application of chemical-shift MR imaging during percutaneous acetic acid chemical ablation procedures in rabbits bearing liver tumor. Methods VX2 tumors were carried out in 18 rabbits. Chemical-shift MR imaging was performed in phantom and VX2 tumors rabbits during percutaneous chemical ablation with FRFSE on a 1.5T MR scanner. Results Phantom data demonstrated focal increases in the observed signal in chemical-shift MR imaging that correlated well with the site of injection. The study in a hepatic VX2 tumor of rabbits revealed focal signal at the injection site. It was significant positive in the radiologic-pathologic correlation. Conclusion Chemical-shift MR imaging may be used to visualize the acetic acid distribution during percutaneous chemical ablation procedures. |
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